Background: In the past few months, the coronavirus disease (COVID-19) pandemic has caused extensive economic and social damage. Objective: The purpose of this study was to assess the impact of COVID-19–related measures on partner relationships and sexual and reproductive health in China. Methods: From May 1 to 5, 2020, 3500 young Chinese individuals were recruited through WeChat or Weibo to participate in a survey to obtain information on sexual and reproductive health (eg, sexual desire, frequency of sexual intercourse, sexual satisfaction, etc). The questionnaire also collected demographic data (eg, age, race, education, current financial status, sexual orientation, relationship status, etc). Results: In total, 967 participants were included in the sexual health analysis. Due to the COVID-19 pandemic and related containment measures, 22% of participants (n=212) reported a decrease in sexual desire; 41% (n=396) experienced a decrease in the sexual intercourse frequency; 30% (n=291) reported an increase in the frequency of masturbation; 20% (n=192) reported a decrease in alcohol consumption before or during sexual activities, and 31% (n=298) reported a deterioration in partner relationships during the pandemic. The logistic regression analysis indicated that the following influenced partner relationships: accommodations during the pandemic (P=.046; odds ratio [OR] 0.59; 95% CI 0.30-0.86); exclusive relationship status (yes or no) (P<.001; OR 0.44; 95 % CI 0.27-0.73); sexual desire (P=.02; OR 2.01; 95% CI 1.38-2.97); and sexual satisfaction (P<.001; OR 1.92; 95% CI 1.54-2.50). COVID-19 also caused disruptions in reproductive health services such as prenatal and postnatal care, childbirth and abortion services, contraception availability, and the management of sexually transmitted infections. Conclusions: Our results show that many young people have wide-ranging issues affecting their sexual and reproductive health due to the COVID-19 pandemic and related containment measures. Strategies and guidelines are needed to safeguard the sexual and reproductive health of young people during this pandemic.

Background: The gut microbiome is receiving considerable attention as a potentially modifiable risk factor and therapeutic target for numerous mental and neurological diseases. Objective: This study aimed to explore and assess the difference in the composition of gut microbes and fecal metabolites between women with hypoactive sexual desire disorder (HSDD) and healthy controls. Methods: We employed an online recruitment method to enroll “hard-to-reach” HSDD populations. After a stringent diagnostic and exclusion process based on DSM-IV criteria, fecal samples collected from 24 women with HSDD and 22 age-matched, healthy controls underwent microbiome analysis using 16S ribosomal RNA gene sequencing and metabolome analysis using untargeted liquid chromatography–mass spectrometry. Results: We found a decreased abundance of Ruminococcaceae and increased abundance of Bifidobacterium and Lactobacillus among women with HSDD. Fecal samples from women with HSDD showed significantly altered metabolic signatures compared with healthy controls. The abundance of Bifidobacterium, Lactobacillus, and several fecal metabolites correlated negatively with the sexual desire score, while the number of Ruminococcaceae correlated positively with the sexual desire score in all subjects. Conclusions: Our analysis of fecal samples from women with HSDD and healthy controls identified significantly different gut microbes and metabolic signatures. These preliminary findings could be useful for developing strategies to adjust the level of human sexual desire by modifying gut microbiota. Trial Registration: Chinese Clinical Trial Registry ChiCTR1800020321; http://www.chictr.org.cn/showproj.aspx?proj=34267

To our knowledge, little attention has been paid to the sexual function of health workers. The aim of the present study was to assess the frequency of sexual dysfunction among Chinese doctors. In addition, the risk factors for sexual dysfunction were analyzed. This was a questionnaire-based multicenter cross-sectional survey performed in five large academic medical centers in China. A total of 539 male doctors, 547 female doctors were evaluated. We analyzed doctors' demographic characteristics, quality of life, sexual function and attitudes towards sexual problems. Chinese doctors are at high risk of sexual dysfunction and poor health. The prevalence of sexual dysfunction appears to increase with age, and is associated with various social and demographic factors including monthly income, physical exercise, working hours, night shift and health-related quality. The quality of life and sexual health of doctors deserves special attention as a significant public health concern. Alleviating work pressure, increasing income, improving quality of life and therapeutic sexual problems should be considered comprehensively.

Introduction: Chronic endometritis (CE) is a prolonged, mild inflammation of the endometrial lining. This study investigated the impact of the impact of antibiotic treatment combined with vaginal Lactobacillus on pregnancy outcomes in infertile patients with CE during frozen embryo transfer (FET) cycles.Methods: A retrospective analysis was performed on the clinical data of 7,385 patients who underwent FET. After applying the inclusion and exclusion criteria, 254 patients diagnosed with CE were eligible for inclusion. Of these, 119 patients received antibiotics alone, whereas 135 were treated with a combination of doxycycline and vaginal Lactobacillus. All patients underwent embryo transfer within 6 months following treatment. The general characteristics and pregnancy outcomes of the first FET cycle post-treatment were compared between the two groups.Results: There were no statistically significant differences between the two groups in terms of general characteristics, clinical pregnancy rate, early miscarriage rate, and ectopic pregnancy rate. Patients who received a combination of doxycycline and Lactobacillus showed a higher biochemical pregnancy rate compared to those who received doxycycline alone, though this difference was not statistically significant (70.37% vs. 64.71%, P=0.313). Furthermore, the incidence rate of premature rupture of membranes was lower in the doxycycline-Lactobacillus group than in the doxycycline group (50.00% vs 33.33%, P=0.037).Conclusions: Although this study observed the potential benefits of the antibiotic and vaginal probiotic treatment regimen in increasing the biochemical pregnancy rate and reducing the incidence of premature rupture of membranes, the current findings are insufficient to recommend the combined use of antibiotics and vaginal Lactobacillus as an intervention to improve reproductive outcomes in infertile patients with CE.

Aim: Despite having been introduced into ICD-11, the appropriate classification and symptomatology of compulsive sexual behavior disorder (CSBD) remain controversial.Methods: In this review, we examined the historical background, epidemiological status quo, comorbidities, neuroscience theories, current diagnoses, and treatment recommendations for CSBD. Additionally, we emphasized the limitations of the current research and the prospects for future work.Results: Psychotherapy and cognitive-behavioral therapy are the preferred treatment methods for CSBD. Selective serotonin reuptake inhibitors and naltrexone are commonly used as “off-label” drugs. The diagnosis and treatment of patients with CSBD should integrate biological, psychological, and social factors with expertise in sexual medicine by employing a comprehensive and holistic therapeutic approach. This treatment aims not only to control abnormal sexual desires and behaviors but also to assist patients in achieving a healthy and satisfying sexual life and well-being.Conclusion: Future research should focus on understanding etiology, improving study population representation, correcting methodological flaws in treatment evaluation, enhancing clinician training in sexual medicine, and addressing patients’ addictions and sexual function issues. Narrowing these research gaps is crucial for improving clinical diagnosis and treatment levels and formulating targeted social intervention measures.