Consumption of high-fructose corn syrup (HFCS) in the diet is a causal factor in the development of abdominal obesity; however, the molecular mechanism behind this association is still up for debate. This study evaluated the metabolic disturbances that are caused by HFCS on adipose tissue as well...

Background: The use of fat grafts in plastic, reconstructive, and aesthetic surgery has been increasing. Although fat grafting has many advantages, there is limited evidence regarding its survival rates. Current studies focus on improving fat graft survival rates. This study aimed to evaluate the effect of therapeutic ultrasound (TERUS) application on fat graft survival. Methods: The study involved 42 adult male Wistar Albino rats, which were randomly divided into seven groups of six rats each: Group 1 served as the control group and received only fat grafting; Group 2 received preoperative daily TERUS for one week, followed by fat grafting; Group 3 underwent preoperative daily massage for one week, followed by fat grafting; Group 4 received preoperative daily TERUS for one week, followed by fat grafting and postoperative daily TERUS for one week; Group 5 underwent preoperative daily massage for one week, followed by fat grafting and postoperative daily massage for one week; Group 6 received postoperative daily TERUS for one week; and Group 7 received postoperative daily massage for one week. After volume and weight measurements, immunohistochemical evaluation was conducted using perilipin and PECAM-1. Apoptosis was assessed using the TUNEL method. Results: No statistically significant differences were observed in the macroscopic measurements. While TERUS increased the vascularization of fat grafts, it did not improve survival rates. The mean fat graft survival rate in the preoperative–postoperative massage group (Group 5) was statistically significantly higher than in the other groups. Conclusions: The findings of this study suggest that the massage effect of TERUS, independent of ultrasonic energy, may be beneficial for fat graft survival. Although TERUS increases the vascularity of fat grafts, it does not improve fat graft survival rates. No Level Assigned: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

This study investigate the histopathological changes and VEGF, IL-1β, and IL-6 immunoreactivities in cornea treated with Coenzyme Q10 (CoQ10) in a Streptozocin (STZ) induced diabetic rat model.A to...

OBJECTIVE: Prostate cancer (PC) ranks second among cancer-related deaths in men, and most deaths are caused by metastasis. Integrins, which are cell surface receptors, play an important role in cancer metastasis. It has been shown that integrin alpha2beta1 expression is effective in cell adhesion, migration, and invasion by increasing binding to collagen I in metastatic PCs. Docetaxel chemotherapy is used in PC, but it is ineffective in advanced stages. Amygdalin is a cyanogenic glycoside commonly found in fruit seeds, there is conflict in the literature regarding its effectiveness in cancer treatment. We aimed to compare the effects of Amygdalin and Docetaxel treatments on the DU145 prostate cancer cell line on integrinalfa2 (ITGA2) and integrinbeta1 (ITGB1) expressions, as well as their effects on cell death, Caspase-3, and Beclin-1. MATERIAL AND METHODS: Propagated DU145 cells were divided into four groups. Amygdalin was given to the first group, Docetaxel was given to the second group, and Amygdalin andDocetaxel were given together to the third group. They were exposed to the active substances for 24 hours. The fourth group (Control) was not given any substance. mRNA levels of ITGA2 and ITGB1 genes were determined by the Real-time PCR method. Caspase-3 and Beclin-1 staining were performed immunocytochemically to evaluate cell death. RESULTS: There was an increase in ITGA2 and ITGB1 expressions in the groups administered by Amygdalin and by Docetaxel (P<0.05). The decrease in ITGB1 expression was significant in the group given Amygdalin+Docetaxel (P<0.001). Caspase-3 (P<0.05) and Beclin-1 (P<0.05) immunoreactivities were observed to increase in all three groups compared to the control group. CONCLUSIONS: It was observed that Docetaxel increased cell death more than Amygdalin in DU145 PC cells, and when Amygdalin and Docetaxel were used together, ITGA2 and ITGB1 expressions were significantly reduced. Our results suggest that dual treatment of Amygdalin and Docetaxel may prevent prostate cancer metastases.

The book "Current Developments in Histology and Embryology" aims to convey the latest approaches in the rapidly changing field of modern cellular and molecular biology to researchers, clinicians, and graduate students in an organized manner. It compiles important new ideas across various areas, including neuroinflammation and neuroprotection strategies, artificial intelligence applications in reproductive medicine, developments in human sperm flagellum ion channels, the role of Clara cell-derived CC16 in lung diseases, exosomes, the role of serotonin in the gut-brain axis, ovarian organization, and placental invasion. Written by expert authors, the text offers a comprehensive look at both basic information and recent scientific data, establishing it as a current and valuable source for the literature.