In air conditioning systems, air curtains play a crucial role in reducing the exchange of hot and cold air between the interior and exterior environments. Nevertheless, the majority of current air curtains suffer from limited airtightness and real-time performance due to their complex jet trajectory, relying on traditional control methods. Thus, this paper introduces an angle control algorithm for air curtains based on a GA-optimized quadratic BP neural network. Initially, the BP neural network is trained using the Hayes dataset to develop the prediction model for temperature-jet angle. Subsequently, the optimization model for jet angles-windshield angle is constructed, and the optimal angles set meeting the fitness function is identified using GA global search. Later, the prediction model and the optimal angles set are once again trained using the BP neural network to generate prediction model for temperature-jet angles and windshield angle. Following CFD simulation, the airtightness indicator demonstrated a 26.5% improvement with the proposed control method compared to traditional ones, highlighting the superior airtightness. In comparison to other algorithms, the proposed algorithm demonstrates a remarkable 89% enhancement in real-time performance and stronger robustness. This study presents a novel approach for the intelligent control of air curtains, holding significant importance in advancing the intelligent development of air curtain technology and facilitating energy efficiency and emission reduction.