In modern societies, the rampant growth of the Internet, both on the technological and social level, has created fertile ground for the emergence of new types of risk. On top of that, it enhances pre-existing threats by offering new means for accessing and exploiting Critical Infrastructures. As the kinds of potential threats evolve, the security, safety and resilience of these infrastructures must be updated accordingly, both at a prevention, as well as a real-time confrontation level. Our research approaches the security of these infrastructures with a focus on the data and utilization of every possible piece of information that derives from this ecosystem. Such a task is quite daunting, since the quantity of data that requires processing resides in the Big Dataspace. To address this, we introduce a new well-defined Information Life Cycle in order to properly model and optimise the way information flows through a modern security system. This life cycle covers all the possible stages, starting from the collection phase up until the exploitation of information intelligence. That ensures the efficiency of data processing and filtering while increasing both the veracity and validity of the final outcome. In addition, an agile Framework is introduced that is optimised to take full advantage of the Information Life Cycle. As a result, it exploits the generated knowledge taking the correct sequence of actions that will successfully address possible threats. This Framework leverages every possible data source that could provide vital information to Critical Infrastructures by performing analysis and data fusion being able to cope with data variety and variability. At the same time, it orchestrates the pre-existing processes and resources of these infrastructures. Through rigorous testing, it was found that response time against hazards was dramatically decreased. As a result, this Framework is an ideal candidate for strengthening and shielding the infrastructures’ resilience while improving management of the resources used.

Data handling and provisioning play a dominant role in the structure of modern cloud–fog-based architectures. Without a strict, fast, and deterministic method of exchanging data we cannot be sure about the performance and efficiency of transactions and applications. In the present work we propose an architecture for a Data as a Service (DaaS) Marketplace, hosted exclusively in a cloud environment. The architecture includes a storage management engine that ensures the Quality of Service (QoS) requirements, a monitoring component that enables real time decisions about the resources used, and a resolution engine that provides semantic data discovery and ranking based on user queries. We show that the proposed system outperforms the classic ElasticSearch queries in data discovery use cases, providing more accurate results. Furthermore, the semantic enhancement of the process adds extra results which extend the user query with a more abstract definition to each notion. Finally, we show that the real-time scaling, provided by the data storage manager component, limits QoS requirements by decreasing the latency of the read and write data requests.

The accurate “base pairing” in RNA molecules, which leads to the prediction of RNA secondary structures, is crucial in order to explain unknown biological operations. Recently, COVID-19, a widespread disease, has caused many deaths, affecting humanity in an unprecedented way. SARS-CoV-2, a single-stranded RNA virus, has shown the significance of analyzing these molecules and their structures. This paper aims to create a pioneering framework in the direction of predicting specific RNA structures, leveraging syntactic pattern recognition. The proposed framework, Knotify+, addresses the problem of predicting H-type pseudoknots, including bulges and internal loops, by featuring the power of context-free grammar (CFG). We combine the grammar’s advantages with maximum base pairing and minimum free energy to tackle this ambiguous task in a performant way. Specifically, our proposed methodology, Knotify+, outperforms state-of-the-art frameworks with regards to its accuracy in core stems prediction. Additionally, it performs more accurately in small sequences and presents a comparable accuracy rate in larger ones, while it requires a smaller execution time compared to well-known platforms. The Knotify+ source code and implementation details are available as a public repository on GitHub.