The synthesis of 14-aryl 14H-dibenzo[a,j]xanthenes is achieved by a simple condensation reaction between β-naphthol with aryl or alkyl aldehydes in an effective synergetic catalytic system created by combining basic bleaching earth clay and PEG-600. The advantages of the present method include catalyst recyclability, superior product yield, a shorter reaction time and the avoidance of hazardous reagents. Synthesized xanthene derivatives were also screened for their antibacterial activity against Staphylococcus aureus (MTCC 96) and Pseudomonas aeruginosa (Wild).

Background: Bimetallic catalysis plays a major role in boosting the catalytic performance of monometallic counterparts due to the synergetic effect. Method and Materials: In the present study, we have exploited ZrCl4:Mg(ClO4)2 as an efficient bimetallic catalyst for the synthesis of a few biologically relevant N-substituted decahydroacridine-1,8-diones and xanthene-1,8-diones under solvent-free conditions. The complete characterization data (XRD, SEM, BET, pH, TGA, and IR) of the bimetallic catalyst, ZrCl4: Mg(ClO4)2, are provided in the supporting information. Results: Among the compounds screened for anti-oxidant and anti-microbial activities, the acridine derivatives with chloro and fluoro substitutions (compounds 4b, 4c, 4d, and 4j) have exhibited potent activities when compared to other compounds. Among the xanthene derivatives screened for anti-oxidant activity, compounds 5c, 5i, and 5j with chloro and nitro derivatives exhibited potent antioxidant activity, and the rest all showed moderately potent activity. Conclusion: Among the compounds screened for antibacterial activity, compound 5j with chloro substitution showed potent activity, followed by compounds 5c, 5d, 5h, and 5i against Gram +ve bacteria, and compounds 5h, 5f, and 5g with N,N-dimethyl, methoxy and hydroxy substitutions have shown potent activity against Gram -ve bacteria.

A series of novel indole quinoline derived chalcones were synthesized using cost-effective synergetic catalytic system consisting of heterogeneous basic bleaching earth clay (pH 12.5) and PEG-400 as solvent at ambient temperature with the yields of 60-76%. All these chalcones were characterized by spectral data. Both the DPPH and SOR scavenging assays were performed to evaluate their antioxidant nature of these compounds.

Berberis aristata (Berberidaceae) is an influential medicinal plant and found in the different provinces of the world. It has compelling medicinal value in the traditional Indian system of medicine. More multitudinous secondary metabolites are contemporary within the plants, which helps to cure the disease. The chromatographic techniques have significant role in natural products chemistry and discovery of innovative compounds of pharmaceutical and biomedical importance. The aim of the present study is to evaluate sequestration of secondary metabolites using column-chromatographic techniques and this metabolites can be further secluded, identified by using LC-ESI-Q-TOF-MS system and also performed its antimicrobial activity. These metabolites were characterized for determination of medicinal properties. This study helps to identify the presence of secondary metabolic compounds in the plant.

Plant metabolites with therapeutic values provide enormous scope for novel drug leads. In this context several traditional medicinal plants are targeted for phytochemicals identification and characterization worldwide. The current investigation was undertaken to identify metabolites present in seeds of Abrus precatorius (L.), a medicinal plant with potent anti-inflammatory, antimicrobial, antioxidant, antifertility, and antispermatogenic activity. Ethanol extracted seed metabolites were identified by LC-ESI-Q-TOF-MS system equipped with a G4220B pump, G4226A auto sampler and G1316C, and a diode array detector. Metabolites profiling yielded large sets of data were analyzed by METLIN Mass Spectral Database. Metabolomics analysis revealed presence of Desethyletomidate, Butabarbital, 4-aminohippurate, 20α-Dihydroprogesterone glucuronide, Phenethylamine, Etomidate, Oxyquinoline, Norfloxacin, Phenylethylmalonamide (PEMA), and Dihydro streptomycin with typical plants metabolites. The masses of these uncommon metabolites were 216.08, 212.11, 222.09, 492.27, 121.09, 244.12, 145.05, 319.12, 206.10 and 567.28 respectively. These metabolites contribute to various drug preparations used to treat human ailments.

Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads because of unmatched availability of chemical diversity. The present study is performed to investigate the presence of phytochemicals for using selected medicinal plant such as Abrus precatorius (L.) Soxhlet apparatus was used for the organic solvent extraction. Abrus precatorius (L.) an important medicinal plant is enriched with remarkable highly potent anti-inflammatory, antimicrobial, antioxidant, antifertility, antispermatogenic activity. Metabolites are identified by high resolution mass spectrometry (HR-LCMS). These metabolites are found in various drug compounds used for drug industry as well as in Ayurveda, folk, Homeopathy, Sidha and Unani.