Contact with nature is believed to enhance mental health through the process of human psychological restoration. However, prolonged indoor living limits individuals’ exposure to nature, potentially hindering the timely alleviation of stress and fatigue induced by work. While biophilic design is recognized as a potential solution, its impact on the restoration process has not been extensively studied, particularly in relation to its various design patterns. Therefore, it is important to determine the restorative effects of different patterns of biophilic design and their combination in order to guide the practical application of biophilic design. In this study, the effects of two typical biophilic design patterns and their combination on attention restoration were measured using subjective scales, cognitive tasks, and functional near-infrared spectroscopy (fNIRS) in a simulated real workspace. The results suggest a significant enhancement in the restorative impact on cognitive performance and physiological benefits when combining two biophilic design patterns, while a single design pattern does not yield the same effect. These findings contribute to a better understanding and improvement of workspaces, enhancing users’ experience and well-being.