A host of anti-hyperglycemic agents are currently available and widely prescribed for diabetes and weight loss management. In patients undergoing surgery, use of these agents poses a clinical challenge to surgeons, anesthesiologists, and other perioperative care providers with regard to optimal timing of discontinuation and resumption of use, as well as possible effects of these agents on physiology and risk of postoperative complications. Here, we provide a comprehensive review of anti-hyperglycemic medications’ effects on physiology, risks/benefits, and best practice management in the perioperative setting. Additionally, we report an illustrative case of small bowel obstruction in a patient taking semaglutide for 6 months prior to an otherwise uncomplicated laparoscopic hysterectomy and bilateral salpingo-oophorectomy. This review is meant to serve not as a replacement of, but rather as a consolidated complement to, various society guidelines regarding perioperative anti-hyperglycemic agent management.

This study aimed to evaluate risk factors for endometrial intraepithelial neoplasia/malignancy in premenopausal women with abnormal uterine bleeding or oligomenorrhea. Specifically, we aimed to elu... 目的：本研究旨在评估绝经前异常子宫出血或月经过少女性子宫内膜上皮内瘤变（EIN）/恶变的危险因素。具体地说, 我们的目的是阐明体重指数（BMI）或年龄是否具有更高的风险。研究设计：在一家大型学术中心进行了一项回溯性队列研究, 调查绝经前接受子宫内膜采样的女性子宫内膜增生/恶变的危险因素。结果：1987年至2019年, 在4170名年龄在18-51岁的女性中, 77人（1.85%）被发现患有E...