Interest in edible and medicinal macrofungi is millennial in terms of their uses in health and food products in Central Asia, while interest in inedible and medicinal macrofungi has grown in popularity in recent years. Edible and inedible medicinal basidiomycetes were collected during field surveys from different regions of Uzbekistan. The morphological characters and similarity assessment of rDNA-Internal Transcribed Spacer sequence data were used to measure diversity and habitat associations. A number of 17 species of medicinal macrofungi of ethnomycological and medicinal interest was found associated with 23 species of trees and shrubs belonging to 11 families and 14 genera. Polyporaceae and Hymenochaetaceae were represented by the highest number of species followed by Ganodermataceae, Fomitopsidaceae, Auriculariaceae, Cerrenaceae, Grifolaceae, Phanerochaetaceae, Laetiporaceae, Schizophyllaceae, and Stereaceae. The highest number of medicinal basidiomycete species was reported in the following host genera: Acer, Betula, Celtis, Crataegus, Juglans, Juniperus, Lonicera, Malus, Morus, Platanus, Populus, Prunus, Quercus, and Salix. An updated list of edible and inedible medicinal mushrooms identified in Uzbekistan, their morphological characteristics, and phylogenetic placement are given for the first time. Information is provided on their uses in traditional and modern medicine. Their bioactive compounds and extracts can be applied as medicines, as well as food and cosmetic ingredients.

Central Asia, located at the heart of Eurasia, is renowned for its varied climate and vertical vegetative distribution, which support diverse biomes and position it as a global biodiversity hotspot. Despite this ecological richness, Central Asia’s fungal diversity, particularly wood-inhabiting macrofungi, remains largely unexplored. This study investigates the diversity, ecological roles, and potential distribution of poroid Hymenochaetoid fungi in the region. By conducting field surveys, collecting basidiomes, and reviewing the literature and herbarium records from five Central Asian countries, we compiled a comprehensive checklist of these fungi. In total, 43 Hymenochaetoid species belonging to 18 genera were identified, with Inonotus, Phellinus, and Phylloporia being the most species-rich. Notably, Inonotus hispidus and Phellinus igniarius were found to be the most widespread species. These macrofungi play essential ecological roles as saprotrophs and pathogens of various identified host plant families, aiding in lignin degradation and exhibiting diverse enzymatic activities. For the first time, we modelled the potential distribution patterns of Hymenochaetoid fungi in Central Asia, revealing that their distribution is strongly influenced by host plant availability and temperature-related factors. The three most critical variables were host plant density, annual temperature range (Bio7), and mean temperature of the warmest quarter (Bio10). The distribution of suitable habitats is uneven, with highly suitable areas (4.52%) concentrated in the mountainous border regions between Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan. These results underscore the significance of specific environmental conditions for the growth and survival of Hymenochaetoid fungi in this region. Our findings highlight the urgent need for continued mycological and host plant research and expanded conservation initiatives to document and preserve macrofungal and botanical biodiversity in this under-explored area. In light of climate change, the collected mycological and botanical data provide a valuable reference for promoting forest health management globally.

Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats. Drawing on literature from 1977 to August 2025, we evaluate their taxonomic diversity, secondary metabolites, and pharmacological activities. Key metabolite classes include polysaccharides (notably β ‐glucans), lanostane‐type triterpenoids, phenolic acids, styrylpyrone derivatives, sterols, and sesquiterpenoids. These compounds display a broad spectrum of bioactivities, including antioxidant, antimicrobial, anticancer, immunomodulatory, anti‐inflammatory, hepatoprotective, and hypoglycemic effects. While globally recognized taxa such as Inonotus obliquus and Phellinus igniarius are well studied, most Central Asian endemics remain poorly characterized, highlighting a substantial untapped reservoir of therapeutic potential. Key challenges include unresolved taxonomy, nonstandardized metabolomic methodologies, limited mechanistic pharmacology, and insufficient ethnomycological and conservation data. To address these gaps, we propose a roadmap integrating multilocus phylogenomics, harmonized metabolomic workflows (LC‐MS/MS, GC–MS, NMR), and targeted in vitro, in vivo, and in silico pharmacological studies, supported by community‐based ethnomycological surveys and IUCN‐aligned conservation strategies. Future progress will require coupling these approaches with advanced omics technologies and AI‐enabled drug discovery to accelerate the translation of fungal metabolites into clinical candidates and nutraceuticals. At the same time, climate‐responsive conservation frameworks are urgently needed to safeguard this unique fungal reservoir. By linking biodiversity with translational pharmacology, this review positions Central Asian Hymenochaetoid fungi as a promising frontier for global natural product discovery and sustainable biotechnological innovation.