In Li and Atick's [1, 2] theory of efficient stereo coding, the two eyes' signals are transformed into uncorrelated binocular summation and difference signals, and gain control is applied to the summation and differencing channels to optimize their sensitivities. In natural vision, the optimal channel sensitivities vary from moment to moment, depending on the strengths of the summation and difference signals; these channels should therefore be separately adaptable, whereby a channel's sensitivity is reduced following overexposure to adaptation stimuli that selectively stimulate that channel. This predicts a remarkable effect of binocular adaptation on perceived direction of a dichoptic motion stimulus [3]. For this stimulus, the summation and difference signals move in opposite directions, so perceived motion direction (upward or downward) should depend on which of the two binocular channels is most strongly adapted, even if the adaptation stimuli are completely static. We confirmed this prediction: a single static dichoptic adaptation stimulus presented for less than 1 s can control perceived direction of a subsequently presented dichoptic motion stimulus. This is not predicted by any current model of motion perception and suggests that the visual cortex quickly adapts to the prevailing binocular image statistics to maximize information-coding efficiency.

Humans can perceive depth when viewing with one eye, and even when viewing a two-dimensional picture of a three-dimensional scene. However, viewing a real scene with both eyes produces a more compelling three-dimensional experience of immersive space and tangible solid objects. A widely held belief is that this qualitative visual phenomenon (stereopsis) is a by-product of binocular vision. In the research reported here, we empirically established, for the first time, the qualitative characteristics associated with stereopsis to show that they can occur for static two-dimensional pictures without binocular vision. Critically, we show that stereopsis is a measurable qualitative attribute and that its induction while viewing pictures is not consistent with standard explanations based on depth-cue conflict or the perception of greater depth magnitude. These results challenge the conventional understanding of the underlying cause, variation, and functional role of stereopsis.

The processing of visual information by the nervous system requires significant metabolic resources. To minimize the energy needed, our visual system appears to be optimized to encode typical natural images as efficiently as possible. One consequence of this is that some atypical images will produce inefficient, non-optimal responses. Here, we show that images that are reported to be uncomfortable to view, and that can trigger migraine attacks and epileptic seizures, produce relatively non-sparse responses in a model of the primary visual cortex. In comparison with the responses to typical inputs, responses to aversive images were larger and less sparse. We propose that this difference in the neural population response may be one cause of visual discomfort in the general population, and can produce more extreme responses in clinical populations such as migraine and epilepsy sufferers.