Despite initial changes in respiratory illness epidemiology due to SARS-CoV-2, influenza activity has returned to pre-pandemic levels, highlighting its ongoing challenges. This paper investigates an influenza epidemic model using a Susceptible-Exposed-Infected-Recovered (SEIR) framework, extended with fuzzy Atangana–Baleanu–Caputo (ABC) fractional derivatives to incorporate uncertainty (via fuzzy numbers for state variables) and memory effects (via the ABC fractional derivative for non-local dynamics). We establish the theoretical foundation by defining the fuzzy ABC derivatives and integrals based on the generalized Hukuhara difference. The existence and uniqueness of the solutions for the fuzzy fractional SEIR model are rigorously proven using fixed-point theorems. Furthermore, we analyze the system’s disease-free and endemic equilibrium points under the fractional framework. A numerical scheme based on the fractional Adams–Bashforth method is used to approximate the fuzzy solutions, providing interval-valued results for different uncertainty levels. The study demonstrates the utility of fuzzy fractional calculus in providing a more flexible and potentially realistic approach to modeling epidemic dynamics under uncertainty.

This study introduces a new class of coupled differential systems described by fractal–fractional Caputo derivatives with both constant and state-dependent delays. In contrast to traditional delay differential equations, the proposed framework integrates memory effects and geometric complexity while capturing adaptive feedback delays that vary with the system’s state. Such a formulation provides a closer representation of biological and physical processes in which delays are not fixed but evolve dynamically. Sufficient conditions for the existence and uniqueness of solutions are established using fixed-point theory, while the stability of the solution is investigated via the Hyers–Ulam (HU) stability approach. To demonstrate applicability, the approach is applied to two illustrative examples, including a predator–prey interaction model. The findings advance the theory of fractional-order systems with mixed delays and offer a rigorous foundation for developing realistic, application-driven dynamical models.

Rotavirus remains a leading cause of gastroenteritis in children under five in low- and middle-income countries due to waning immunity and incomplete vaccine coverage. To address this, we propose a mathematical model to analyze the transmission dynamics with primary and booster vaccination strategies. The model is formulated using the fractal-fractional derivative in the Caputo-Fabrizio sense, which allows for the incorporation of memory effects and hereditary properties in disease evolution. The population is structured into five compartments, including booster-immunized individuals. We derive the disease-free and endemic equilibrium points and analyze their local stability. The basic reproduction number is computed to determine the threshold conditions for disease persistence. We establish the existence and Hyers-Ulam (H-U) stability of the model, and validate the results through numerical simulations using the Adams-Bashforth method (ABM), confirmed by comparison with Runge-Kutta 4th Order (RK-4) solution plots to assess the booster vaccination impact. The results reveal that booster immunization plays a significant role in reducing the infection burden, thereby highlighting its relevance in public health planning.

Polycystic Ovary Syndrome (PCOS) is a widespread hormonal disorder affecting women of reproductive age, often leading to infertility and associated complications. This study presents a comprehensive stochastic mathematical framework to analyze the dynamics of PCOS with a particular focus on infertility and treatment outcomes. Here, the transitions between compartments represent progression of women through clinical states of PCOS (risk, diagnosis, treatment, recovery) rather than infection or transmission, since PCOS is a non-communicable disorder. The model incorporates probabilistic elements to break the symmetric and predictable assumptions inherent in deterministic approaches. This allows it to reflect the randomness and asymmetry in hormonal regulation and ovulation cycles, enabling a more realistic representation of disease progression. By utilizing stochastic differential equations, the study evaluates the impact of treatment adherence on fertility restoration. We establish the conditions for disease extinction versus the existence of an ergodic stationary distribution, which represents a form of long-term statistical symmetry. The results emphasize the importance of early diagnosis and consistent treatment. Furthermore, the proposed approach provides a valuable tool for clinicians to predict patient-specific trajectories and optimize individualized treatment plans, accounting for the asymmetric nature of patient responses.