One of the critical challenges in mobile robotics is obstacle avoidance, ensuring safe navigation in dynamic environments. In this sense, this work presents a comparative study of two intelligent control approaches for mobile robot obstacle avoidance based on a fuzzy architecture. The first approach is a neuro-fuzzy interface that combines neural networks’ learning capabilities with fuzzy logic’s rule-based reasoning, offering a flexible and adaptable control strategy. The second is a classic Mamdani fuzzy system that relies on human-defined fuzzy rules, providing an intuitive approach to control. A key contribution of this work is the development of a fast comprehensive, model-based dataset for neural network training generated without the need for real sensor data. The results show the evaluation of these two systems’ performance, robustness, and computational efficiency using low-cost ultrasonic sensors on a Pioneer 3DX robot within the Coppelia Sim environment.