▪ Abstract The micromachining technology that emerged in the late 1980s can provide micron-sized sensors and actuators. These micro transducers are able to be integrated with signal conditioning and processing circuitry to form micro-electro-mechanical-systems (MEMS) that can perform real-time distributed control. This capability opens up a new territory for flow control research. On the other hand, surface effects dominate the fluid flowing through these miniature mechanical devices because of the large surface-to-volume ratio in micron-scale configurations. We need to reexamine the surface forces in the momentum equation. Owing to their smallness, gas flows experience large Knudsen numbers, and therefore boundary conditions need to be modified. Besides being an enabling technology, MEMS also provide many challenges for fundamental flow-science research.

In the present study, it is shown that the spreading rate of a mixing layer can be greatly manipulated at very low forcing level if the mixing layer is perturbed near a subharmonic of the most-amplified frequency. The subharmonic forcing technique is able to make several vortices merge simultaneously and hence increases the spreading rate dramatically. A new mechanism, ‘collective interaction’, was found which can bypass the sequential stages of vortex merging and make a large number of vortices (ten or more) coalesce.A deeper physical insight into the evolution of the coherent structures is revealed through the investigation of a forced mixing layer. The stability and the forcing function play important roles in determining the initial formation of the vortices. The subharmonic starts to amplify at the location where the phase speed of the subharmonic matches that of the fundamental. The position where vortices are seen to align vertically coincides with the position where the measured subharmonic reaches its peak. This location is defined as the merging location, and it can be determined from the feedback equation (Ho & Nosseir 1981).The spreading rate and the velocity profiles of the forced mixing layer are distinctly different from the unforced case. The data show that the initial condition has a longlasting effect on the development of the mixing layer.

A passive technique of increasing entrainment was found by using a small-aspect-ratio elliptic jet. The entrainment ratio of an elliptic jet was several times greater than that of a circular jet or a plane jet. The self-induction of the asymmetric coherent structure caused azimuthal distortions which were responsible for engulfing large amounts of surrounding fluid into the jet. In an elliptic jet, an interesting feature in the initial stability process is that the thickness of the shear layer varies around the nozzle. The data indicated that instability frequency was scaled with the thinnest initial momentum thickness which was associated with the maximum vorticity. Turbulence properties were also examined and were found to be significantly different in the major- and minor-axis planes.

Fast advancements of microfabrication processes in past two decades have reached to a fairly matured stage that we can manufacture a wide range of microfluidic devices. At present, the main challenge is the control of nanoscale properties on the surface of lab-on-a-chip to satisfy the need for biomedical applications. For example, poly(dimethylsiloxane) (PDMS) is a commonly used material for microfluidic circuitry, yet the hydrophobic nature of PDMS surface suffers serious nonspecific protein adsorption. Thus the current major efforts are focused on surface molecular property treatments for satisfying specific needs in handling macro functional molecules. Reviewing surface modifications of all types of materials used in microfluidics will be too broad. This review will only summarize recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology and classify them into two main categories: (1) physical approach including physisorption of charged or amphiphilic polymers and copolymers, as well as (2) chemical approach including self assembled monolayer and thick polymer coating. Pros and cons of a collection of available yet fully exploited surface modification methods are briefly compared among subcategories.

Enabled by a technology to fabricate well-defined nanogrates over a large area $(2\times 2{\mathrm{cm}}^2)$ , we report the effect of such a surface, in both hydrophilic and hydrophobic conditions, on liquid slip and the corresponding friction reduction in microchannels. The grates are designed to be dense ($\sim 230\mathrm{nm}$ pitch) but deep $(\sim 500\mathrm{nm})$ in order to sustain a large amount of air in the troughs when the grates are hydrophobic, even under pressurized liquid flow conditions (e.g., more than $1\mathrm{bar}$ ). A noticeable slip (i.e., slip length of $100–200\mathrm{nm}$ , corresponding to 20%–30% reduction of pressure drop in a $\sim 3\mathrm{\mu }\mathrm{m}$ high channel) is observed for water flowing parallel over the hydrophobic nanogrates; this is believed to be an “effective” slip generated by the nanostrips of air in the grate troughs under the liquid. The effective slip is clearer and larger in flows parallel to the nanograting patterns than in transverse, suggesting that the nanograted superhydrophobic surfaces would not only reduce friction in liquid flows under pressure but also enable directional control of the slip. This paper is the first to use nanoscale grating patterns and to measure their effect on liquid flows in microchannels.