Adsorption and desorption behaviors of tetracycline hydrochloride by activated carbon-based adsorbents derived from sugar cane bagasse modified with ZnCl₂ were investigated. The activated carbon was tested by SEM, EDX, BET, XRD, FTIR, and XPS. This activated carbon exhibited a high BET surface area of 831 m² g⁻¹ with the average pore diameter and pore volume reaching 2.52 nm and 0.45 m³ g⁻¹, respectively. The batch experimental results can be described by Freundlich equation, pseudo-second-order kinetics, and the intraparticle diffusion model, while the maximum adsorption capacity reached 239.6 mg g⁻¹ under 318 K. The effects of flow rate, bed height, initial concentration, and temperature were studied in fixed bed adsorption experiments, and adsorption data were fitted with six dynamic adsorption models. The results of characterizations and the batch experiments were analyzed to study the adsorption and desorption mechanisms. Tetracycline hydrochloride and activated carbon were bonded together by π–π interactions and cation–π bonds. Ethanol was used as an eluent which bonded with 10 hydrogen bond acceptors on tetracycline hydrochloride to form a complex by hydrogen bonding to achieve recycling.