Drought, a significant calamity in the natural domain, has extensive worldwide repercussions. Drought, primarily characterized by reduced soil moisture (SM), presents a significant risk to both the world environment and human existence. Various drought indicators have been suggested to accurately represent the changing pattern of SM. The study examines various indices related to the Drought Severity Index (DSI), Evaporation Stress Index(ESI), Vegetation Supply Water Index(VSWI), Temperature-Vegetation Dryness Index(TVDI), Temperature Vegetation Precipitation Dryness Index(TVPDI), Vegetation Health Index(VHI), and Temperature Condition Index (TCI). An evaluation was conducted to assess the effectiveness of seven drought indicators, such as DSI, ESI, TVPDI, VSWI, etc., in capturing the changes in SM in Mu Us Sandy Land. The research results indicated that DSI and ESI had the highest accuracy, while TVDI and VSWI showed relatively lower accuracy. However, their smaller fluctuations in the time series demonstrated stronger adaptability to different regions. Additionally, the delayed impact of aridity indices on soil moisture, variable attributes, temperature, and vegetation coverage in sandy land and grassland areas with low, medium, and high coverage all contributed to the effectiveness of the four aridity indices (DSI, ESI, VSWI, and TVPDI) in capturing the dynamics of soil moisture. The primary element that affects the effectiveness of TVDI is the divergence of the relationship curve between Land Surface Temperature (LST) and Normalized Difference Vegetation Index (NDVI), which is a kind of deterioration. This paper presents a very efficient approach for monitoring soil moisture dynamics in dry and semi-arid regions. It also analyzes the patterns of soil moisture changes, offering valuable scientific insights for environmental monitoring and ecological enhancement.