Valdir Cechinel Filho

Dr. Valdir Cechinel Filho

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Research Focus & Metrics

Academic Career Length

26Years (2001-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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23 January 2009 in Phytotherapy Research
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VFValdir Cechinel Filho
Valdir Cechinel Filho

1 May 2002 in Química Nova
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KSKarina Luize da Silva
Karina Luize da Silva
VFValdir Cechinel Filho
Valdir Cechinel Filho
Plants of the genus Bauhinia (Leguminosae) are widely distributed in most tropical countries and have been frequently used in folk medicine to treat several ailments, especially diabetes. In recent years, the interest in these plants has increased considerably in all world. This review shows the main chemical and pharmacological aspects of these plants. The studies carried out with the extracts and purified compounds from these plants support most of their reported therapeutic properties. It also gives an account of some compounds including terpenes, steroids and flavonoids that were isolated from the genus Bauhinia.

1 May 2003 in Química Nova
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Journal Article
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VNVânia Floriani Noldin
Vânia Floriani Noldin
VFValdir Cechinel Filho
Valdir Cechinel Filho
FMFranco Delle Monache
Franco Delle Monache
JBJean Carlo Benassi
Jean Carlo Benassi
ICIrma Luiza Christmann
Irma Luiza Christmann
RYRosendo Augusto Yunes
Rosendo Augusto Yunes
The present paper describes the chemical composition and biological activities of artichoke cultivated in Brazil. Our studies demonstrated that glycosyl flavonoids (cynaroside and scolymoside), are the major constituents, along with cynaropicrin, a sesquiterpene lactone, and the triterpene lupeol. Cynarin, which is the main compound described for artichoke, was detected in very low concentration. Hexanic fraction exhibited considerable cytotoxicity and diuretic activities

16 February 2012 in Chemistry & Biodiversity
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KJKlein Júnior
Klein Júnior
LCLuiz Carlos
Luiz Carlos
FAFaloni de Andrade
Faloni de Andrade
SÉSérgio
Sérgio
VFValdir Cechinel Filho
Valdir Cechinel Filho

1 March 2003 in Química Nova
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VFValdir Cechinel Filho
Valdir Cechinel Filho
FCFátima de Campos
Fátima de Campos
RCRogério Corrêa
Rogério Corrêa
RYRosendo A. Yunes
Rosendo A. Yunes
RNRicardo J. Nunes
Ricardo J. Nunes
Cyclic imides consists of an important family of organic compounds with therapeutic potential. In this review, emphasis will be given to the chemical and biological aspects of several sub-classes of this family, incluing maleimides, succinimides, glutarimides, naphtalimides, etc. Additionally, will be focused the contribution of our research group in this field

30 April 2007 in Molecules
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FCFátima De Campos-Buzzi
Fátima De Campos-Buzzi
PPPâmela Padaratz
Pâmela Padaratz
AMAleandra Vergilina Meira
Aleandra Vergilina Meira
RCRogério Corrêa
Rogério Corrêa
RNRicardo José Nunes
Ricardo José Nunes
VFValdir Cechinel Filho
Valdir Cechinel Filho
Nine acetamidochalcones were synthesized and evaluated as antinociceptive agents using the mice writhing test. Given intraperitoneally all the compounds were more effective than the two reference analgesic drugs (acetylsalicylic acid and acetaminophen) used for comparison. N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]phenyl}acetamide (6) was the most effective compound and was therefore selected for more detailed studies. It caused dose-related inhibition in the writhing test, being about 32 to 34-fold more potent than the standard drugs. It was also effective in the second phase of the formalin test and the capsaicin test. These acetamidochalcones, especially compound 6, might be further used as models to obtain new and more potent analgesic drugs.