Paula Cordova Alegre

Dr. Paula Cordova Alegre


Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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13 November 2024 in Journal of Clinical Medicine
Verified
Journal Article
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PAPaula Cordova Alegre
Paula Cordova Alegre
Pablo HerreroPablo Herrero
Pablo Herrero
SSSonia Santos-Lasaosa
Sonia Santos-Lasaosa
MNMaria Pilar Navarro-Perez
Maria Pilar Navarro-Perez
BCBeatriz Carpallo
Beatriz Carpallo
CJCarolina Jiménez-Sánchez
Carolina Jiménez-Sánchez
Background/Objectives: Chronic migraine (CM) is a neurological disorder that causes significant disability, loss of productivity, and economic burden. Preventive treatments, including pharmacological and educational interventions, are crucial for managing CM effectively. The aim of this study was to analyze whether adding a therapeutic telehealth education program (TTEP) to pharmacological treatment achieved a greater reduction in the number of headache days experienced by patients with CM. Methods: A randomized, double-blind, controlled pilot study with two parallel groups was performed. Patients with a diagnosis of CM and who were being treated with Botulinum Toxin were randomly assigned to either the EG (therapeutic education program about the neuroscience of pain, migraine, pain strategies, sleep habits, exercise, nutrition, postural habits, and relaxation strategies) or CG (general health recommendations with no specific content about migraine). The intervention lasted a total of eight weeks and was delivered via a telehealth application (APP). Headache frequency, migraine frequency, pain intensity, headache impact, allodynia, fear of movement, pain catastrophizing, chronic pain self-efficacy, anxiety and depression, sleep quality, and sedentary lifestyle were measured at baseline (M0), one month after the intervention started (M1), at the end of the intervention (M2), and one month after the intervention was completed for follow-up (M3). Results: In total, 48 patients participated. There were differences between the groups in the following outcomes in favor of EG for headache frequency at the one-month follow-up (p = 0.03; d = 0.681); chronic pain self-efficacy at post-treatment (p = 0.007; d = 0.885) and at the one-month follow-up (p < 0.001; d = 0.998); and sleep quality at post-treatment (p = 0.013; d = 0.786) and at the one-month follow-up (p < 0.001; d = 1.086). No differences existed between the groups for the other outcomes examined (p < 0.05). Conclusions: The use of TTEP reduced the number of headache days, improved sleep quality, and increased self-efficacy in managing pain. This pilot study suggests that the addition of a specialized TTPE to pharmacological treatments may be more effective than a general health recommendation program for migraine.

14 December 2021 in Healthcare
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Journal Article
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ACAlicia López Casaus
Alicia López Casaus
CJCarolina Jiménez-Sánchez
Carolina Jiménez-Sánchez
PAPaula Cordova Alegre
Paula Cordova Alegre
FAFani Alfaro-Gervon
Fani Alfaro-Gervon
LELaura Esteban-Repiso
Laura Esteban-Repiso
RLRaquel Lafuente-Ureta
Raquel Lafuente-Ureta
People with hemophilia usually have negative joint consequences due to their illness. Evidence suggests that exercise and therapeutic education bring some benefits. An important factor that affects health interventions was the experience and degree of satisfaction. Thus, it is relevant to analyze qualitative and quantitative data to obtain a complete view of the patient’s experience. As a result, a concurrent nested mixed method with quantitative predominance study design was carried out. Nine people with hemophilia of Hemoaralar with a homogeneous environment participated in this study. The items evaluated were the level of satisfaction through the GCPC-UN-ESU survey and the experience with healthcare interventions through a focus group. A high level of satisfaction was obtained, but some divergences between quantitative and qualitative data were found. Further research about physical therapy and this type of intervention in people with hemophilia should be considered to better address the impact of living with the disease.

20 March 2025 in Reports
Verified
Journal Article
Open access
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BCBeatriz Carpallo
Beatriz Carpallo
EBEsther Del corral beamonte
Esther Del corral beamonte
CJCarolina Jiménez-Sánchez
Carolina Jiménez-Sánchez
PAPaula Cordova Alegre
Paula Cordova Alegre
NCNatalia Brandín-de la Cruz
Natalia Brandín-de la Cruz
SCSandra Calvo
Sandra Calvo
Background: Post COVID-19 Condition is a recently recognized syndrome characterized by the persistence of various symptoms, including dyspnea, physical and mental fatigue, and post-exertional malaise. Currently, there is no established treatment or clear consensus on the effectiveness of rehabilitation, and given that patients could benefit from home-based rehabilitation, telerehabilitation, defined as remote rehabilitation using telematic systems, may be an option to reach more of the population with persistent COVID-19 symptoms. Therefore, it is necessary to show the efficacy of this telematic approach and the benefits of a multimodal rehabilitation strategy in these patients. Methods: Patients underwent home rehabilitation using a 12-week synchronous telerehabilitation system. The intervention included therapeutic education and physical and respiratory rehabilitation. The following variables were analyzed: Fatigue, quality of life, dyspnea, respiratory strength, aerobic capacity, and upper and lower limb strength. Conclusions: After 12 weeks, significant improvements were found in fatigue, aerobic capacity, and limb and respiratory strength. However, no improvement was found in dyspnea scores, which did not correlate with respiratory strength. Interestingly, a post-intervention correlation emerged between the distance covered in aerobic capacity and perceived fatigue, suggesting that asynchronous telerehabilitation could be a viable treatment strategy for these patients.

25 October 2025 in Annals of Medicine
Verified
Journal Article
Open access
BCBeatriz Carpallo
Beatriz Carpallo
CJCarolina Jiménez-Sánchez
Carolina Jiménez-Sánchez
ILIrene Liñares-Varela
Irene Liñares-Varela
LBLaura Bafaluy-Franch
Laura Bafaluy-Franch
PAPaula Cordova Alegre
Paula Cordova Alegre
SCSandra Calvo
Sandra Calvo
Telerehabilitation has become an important tool for the recovery of coronavirus disease (COVID-19) patients, allowing treatment to be continued remotely for this and other pathologies. Self-efficacy plays a key role in motivating and ensuring adherence to these programs. The aim of this study was to evaluate the effects on self-efficacy (GSES) and sport motivation (BRSQ-36) and analyze the correlation between self-efficacy and physical condition after a program composed of therapeutic exercises and education. This pilot randomized controlled trial included 35 post-discharge COVID-19, with two groups: an asynchronous telerehabilitation and a booklet-based rehabilitation groups who undertook a 12-week intervention of therapeutic exercise and education.. The telerehabilitation group showed better results in all variables analyzed, with moderate and large clinical changes in overall motivation d = 0.8, but no significant changes. At the 3- and 6-month follow-up, statistically significant differences in self-efficacy were found in favor of the telerehabilitation group (3-m, p = 0.025, d = 0.76); 6-m, p = 0.007, d = 0.79). The telerehabilitation group showed better results in 'Extrinsic Motivation' (3-m, p = 0.037, d = 0.75; 6-m, p = 0.010, d = 0.94) and 'Identified Regulation' (3-m, p < 0.001, d = 1.09; 6-m, p = 0.005, d = 0.49) after 3- and 6-month follow-up. . In all patients, a direct correlation was found between self-efficacy and meters walked in the six minutes' walk test (6 MWT) (p = 0.022; R2 = 0.149), '30 STST and 30' ACT (p = 0.002; R2 = 0.261; p = 0.017; R2 = 0.160), respectively; an inverse correlation was found after three months with the fatigue variable (p < 0.001; R2 = 0.2858) and after six months (p < 0.001; R2 = 0.2889). The findings highlight the potential of asynchronous telerehabilitation to improve self-efficacy and extrinsic motivation in a short period of time, which could facilitate better adherence to rehabilitation programs and improve physical condition. However, the results seem to be limited in the long term.

22 March 2025 in Life
Verified
Journal Article
Open access
PDF file
CJCarolina Jiménez-Sánchez
Carolina Jiménez-Sánchez
RFRocío Fortún-Rabadán
Rocío Fortún-Rabadán
BCBeatriz Carpallo
Beatriz Carpallo
PAPaula Cordova Alegre
Paula Cordova Alegre
Luis Espejo-AntúnezLuis Espejo-Antúnez
Luis Espejo-Antúnez
MOMaría Ortiz-Lucas
María Ortiz-Lucas
Background: Adequate hamstring flexibility is crucial for musculoskeletal health as increased muscle tone can lead to stretch-type injuries, muscle weakness, dysfunctional neuromuscular control, postural changes, and lower back pain. The aim was to compare the effectiveness of a program based on Electrical Muscle Elongation (EME), Proprioceptive Neuromuscular Facilitation (PNF), and no intervention in improving flexibility and viscoelastic properties of hamstring and quadriceps muscles in active young adults with functional hamstring disorder (type 2B according to the Munich Consensus). Methods: Sixty-five participants (45 male, 20 female) were randomly assigned to three groups: the EME group (n = 21) received a simultaneous combination of interferential current and stretching, the PNF group (n = 22) underwent active stretching, and the Control group (n = 22) received no intervention. Hamstring and quadricep flexibility and muscle stiffness were measured in both limbs at baseline, post-intervention, and at the 4-week follow-up. Results: The EME group showed significant improvements in hamstring flexibility in the left limb compared to the Control group and in some myotonometric variables of the quadriceps muscle compared to the PNF and Control groups (p < 0.05). Within-groups differences indicated higher improvements in the EME group. Conclusions: This study suggests that EME may offer greater benefits than PNF stretching in young adults with functional hamstring disorder.

4 March 2025 in Preprints.org
Verified
Preprint
Open access
PDF file
BCBeatriz Carpallo
Beatriz Carpallo
EBEsther Del corral beamonte
Esther Del corral beamonte
CJCarolina Jiménez-Sánchez
Carolina Jiménez-Sánchez
PAPaula Cordova Alegre
Paula Cordova Alegre
NCNatalia Brandín-de la Cruz
Natalia Brandín-de la Cruz
SCSandra Calvo
Sandra Calvo
Background and Clinical Significance : Post COVID-19 Condition is a recently recognized syndrome characterized by the persistence of various symptoms, including dyspnea, physical and mental fatigue, and post-exertional malaise. Currently, there is no established treatment or clear consensus on the effectiveness of rehabilitation. In addition, asynchronous telerehabilitation may be an option to reach more of the population with persistent COVID symptoms. Therefore, it is necessary to show the efficacy of this telematic approach and the benefits of a multimodal rehabilitation strategy in these patients. Case Presentation : This study presents a case series of 12 patients (9 women and 3 men) diagnosed with Post COVID-19 Condition and chronic fatigue who underwent rehabilitation through an asynchronous telerehabilitation approach. The 12-week intervention included therapeutic education, physical and respiratory rehabilitation. The most prevalent symptoms were severe fatigue, arthralgias and myalgias, cough and dyspnea and brain fog. The following variables were analyzed: Fatigue, quality of life, dyspnea, respiratory strength, aerobic capacity and upper and lower limb strength. Conclusions: After 12 weeks significant improvements were found in fatigue, aerobic capacity and limb and respiratory strength. However, no improvement was found in dyspnea scores, which did not correlate with respiratory strength. Interestingly, a post-intervention correlation emerged between the distance covered in the aerobic capacity and perceived fatigue, suggesting that asynchronous telerehabilitation could be a viable treatment strategy for these patients.