O estudo objetivou a realização de uma revisão narrativa de literatura sobre o processo de alta hospitalar de pessoas com Acidente Vascular Cerebral (AVC). A busca foi realizada nas bases de dados, PubMed e Google Acadêmico, entre os meses de julho e agosto de 2021. Foram utilizados os descritores: “Stroke”, “discharge planning” OR “Transitional Care” AND “Caregivers”. Como critério de inclusão considerou-se publicações que abordaram o tema, publicadas entre os anos de 2016 a 2021, escritos em idioma português ou inglês e com acesso online. A pré-seleção considerou a leitura de título e resumo das publicaçãoes e classificou ao final 11 para leitura completa. Como principais resultados encontrou-se que o profissional mais envolvido no processo de alta hospitalar de pacientes acometidos por AVC é o enfermeiro (a). Entretanto, parece haver dificuldades no processo de transição do cuidado, principalmente no que se refere a comunicação e envolvimento dos pacientes e cuidadores na tomada de decisão. O planejamento da alta representa estratégia essencial para a transferência do paciente do hospital para casa e pode contribuir para a diminuição: das taxas de reinternação, das complicações, do tempo de internação hospitalar, dos custos de atendimento e de mortalidade. Ainda, destaca-se importância da educação em saúde e do trabalho interprofissional para o cuidado integral de pessoas com AVC.

Objective: An eucalyptus essential oil-based nanoemulsion was produced and evaluated for its antimicrobial properties against Streptococcus mutans and its cytotoxicity in the surface mucous cells of rabbits. Methods: The essential oil-based nanoemulsion was synthesized with two species of eucalyptus—Eucalyptus citriodora and Eucalyptus globulus—followed by physicochemical characterization and the determination of antimicrobial activity and cell viability. Subsequently, the mouthwash formulations (fluoride and fluoride-free) were functionalized with the nanoemulsion, and their in vitro antimicrobial actions were evaluated against S. mutans. Results: The nanoemulsion presented an average particle size of around 100 nm, a polydispersity index close to 0.3, a zeta potential between −19 and −30 mV, a pH close to 7, a spherical shape, and a cell viability above 50%. The antimicrobial activity analysis showed that the nanoemulsion was effective in the control of S. mutans. The mouthwashes functionalized with the nanoemulsion also presented bacteriostatic and bactericidal properties. Conclusions: The bio-based material produced with eucalyptus essential oil presented adequate physicochemical characteristics, with the potential to be used as an innovative material in preventive dentistry, contributing to the maintenance of oral and systemic health.

The presence of artificial intelligence in healthcare is growing, helping in diagnosis and decision making. However, its application raises doubts, mostly related to ethics. This study aimed to identify its uses in health and its bioethical implications from a systematic literature review using the PRISMA guidelines. The ScienceDirect and Scopus databases were searched, using the descriptors “artificial intelligence,” “bioethics” and “health.” Works in English, published between 2017 and 2021 were considered, resulting in 102 articles found and, after applying the established criteria, 11 were selected. The studies reported on the bioethical principles of beneficence, non-maleficence, autonomy and justice, adding an element, explainability. Relationships were found between artificial intelligence in health and unpredictability, predictability, trust, physicians’ role, systems development, privacy, data security, financial and social aspects. Developers, healthcare professionals and patients must maximize the benefits and limit the risks of tools that use this technology.

A presença de inteligência artificial na saúde vem crescendo, ajudando em diagnósticos e tomadas de decisão, mas suas implicações geram dúvidas relacionadas à ética. Esta revisão sistemática, baseada nas diretrizes Prisma, identificou os usos de inteligência artificial na saúde e suas implicações bioéticas. Foi realizada busca nas bases de dados Science Direct e Scopus usando os descritores “artificial intelligence”, “bioethics” e “health”. Trabalhos em inglês, publicados entre 2017 e 2021 foram considerados, resultando em 102 artigos. Após aplicação dos critérios estabelecidos, 11 foram selecionados. Os estudos discutiram os princípios bioéticos da beneficência, não maleficência, autonomia e justiça, adicionando o elemento explicabilidade. Inteligência artificial mostrou correlação com imprevisibilidade, previsibilidade, confiança, papel do médico, desenvolvimento de sistemas, privacidade, segurança de dados, e aspectos sociais e financeiros. Desenvolvedores, profissionais da saúde e pacientes devem maximizar os benefícios e limitar os riscos das ferramentas que usam essa tecnologia.

Introduction: Dental caries is a multifactorial disease with high prevalence, particularly in vulnerable populations, where Streptococcus mutans contributes to lesion progression via acid production and biofilm formation. Minimally invasive strategies, such as photodynamic therapy (PDT) combined with advanced delivery systems, offer promising alternatives for caries management.Methods: Zein-based nanocapsules loaded with curcumin (Nano-curcumin) were synthesized via nanoprecipitation and characterized for encapsulation efficiency, particle size, polydispersity, zeta potential, morphology, and curcumin release. Biocompatibility was assessed using rabbit oral mucosal cells via MTT and trypan blue assays. Antimicrobial efficacy was tested in vitro on primary dentin slices contaminated with S. mutans across four groups: Nano-curcumin, Nano-curcumin + PDT, diode laser, and untreated control. Colony-forming units (CFU) were quantified after treatment. Statistical analysis was performed using ANOVA and Tukey’s test (p < 0.05).Results: Nano-curcumin demonstrated high encapsulation efficiency (~100%), spherical morphology, low polydispersity (0.108), and favorable colloidal stability, with sustained curcumin release over 24 hours. Cytotoxicity assays showed >50% cell viability at 100 μg·mL⁻¹ and ~80% at intermediate concentrations (50–75 µg·mL^-¹). Both curcumin nanocapsules and their photosensitized versions significantly reduced S. mutans CFU compared to controls (p < 0.05), with PDT-enhanced nanocapsules showing the greatest reduction, though not statistically different from non-photosensitized nanocapsules.Discussion: Curcumin-loaded zein nanocapsules are biocompatible and effective against S. mutans, with controlled release properties. Photodynamic activation further enhances antimicrobial activity, supporting their potential as a minimally invasive approach for managing carious lesions, particularly in pediatric dentistry. This strategy integrates a natural photosensitizer with a biodegradable polymeric matrix, providing a safe and innovative alternative for caries control.

Estimar a prevalência de sífilis gestacional (SG) em mulheres atendidas em uma maternidade da Serra Catarinense e conhecer as características sociodemográficas, comportamentais, de uso dos serviços e o desfecho dos recém-nascidos (RN) de gestantes com sífilis. Estudo quantitativo retrospectivo, com coleta de dados de prontuários dos anos de 2015 a 2018. Dos 11.720 prontuários analisados, 515 eram de gestantes admitidas durante o trabalho de parto com teste positivo para sífilis. A prevalência de SG foi de 4,4%. As gestantes tinham idade entre 20-29 anos (56,7%), cor branca (69,3%), solteiras (54,0%), sem trabalho remunerado (69,1%) e baixa escolaridade (49,3%). Observou-se ampla cobertura de acompanhamento de pré-natal (93,6%) e diagnóstico realizado precocemente (41,6%). Entretanto, o tratamento foi considerado inadequado em 78,3% das gestantes e seus parceiros e 6,4% dos RN nasceram com sífilis ativa. Conclui-se alta prevalência de SG na referida maternidade, relacionada com falta de tratamento das gestantes e parceiros. Descritores: Sífilis, Gestantes, Epidemiologia. Prevalence of gestational syphilis and associated factors: a panorama of the Serra Catarinense : To estimate the prevalence of gestational syphilis in women attended at a maternity hospital in Serra Catarinense and to understand the sociodemographic, behavioral, use of services and outcome of newborns of pregnant women with syphilis. Retrospective quantitative study, based on medical records from 2015 to 2018. Of the 11,720 medical records analyzed, 515 were of pregnant women admitted during labor with a positive test for syphilis. A prevalence of gestational syphilis was 4.4%. Pregnant women were between 20-29 years old (56.7%), white (69.3%), single (54.0%), with no paid work (69.1%) and low education level (49.3%). There was wide coverage of prenatal care (93.6%) and early diagnosis (41.6%). However, the treatment was considered inadequate in 78.3% of the pregnant women and their partners and 6.4% of the newborns were born with active syphilis. It is concluded that there is high prevalence of gestational syphilis in referred maternity, related to lack of treatment for pregnant women and partners. Descriptors: Syphilis, Pregnant Women, Epidemiology. Prevalencia de sífilis gestacional y factores asociados: un panorama de la Serra Catarinense Resumen: Estimar la prevalencia de sífilis gestacional (SG) en mujeres atendidas en un hospital de maternidad de la Serra Catarinense y conocer el sociodemográfico, conductual, uso de servicios y evolución de recién nacidos de gestantes con sífilis. Estudio cuantitativo retrospectivo, basado en datos de historias clínicas de 2015 a 2018. De 11.720 historias clínicas analizadas, 515 correspondieron a gestantes ingresadas durante el trabajo de parto con sífilis positiva. La prevalencia de SG fue del 4,4%. Las mujeres embarazadas tenían entre 20 y 29 años (56,7%), blancas (69,3%), solteras (54,0%), sin trabajo remunerado (69,1%) y bajo nivel educativo (49,3%). Se observó amplia cobertura de atención prenatal (93,6%) y diagnóstico precoz (41,6%). Tratamiento inadecuado en el 78,3% de las embarazadas y sus parejas y el 6,4% de los recién nacidos con sífilis activa. Se concluye alta prevalencia de SG en maternidad referida, relacionada con falta de tratamiento en gestantes y parejas. Descriptores: Sífilis, Mujeres Embarazadas, Epidemiología.