When an external field was applied, the refractive index of the magnetic fluid film was observed to be modulated as the field exceeded a critical strength. We found that the stronger the magnetic field, the higher the refractive index. By taking both the formation of the columns and the variation in the concentration of the liquid phase in magnetic fluid films under external magnetic fields into account, the refractive index was calculated and compared with experimental data. When we did this, we noticed a consistency that implies that the phase separation leads to the variation in the refractive index of the magnetic fluid film as the magnetic field strength is changed. With such a property as a tunable refractive index, the feasibility of using a magnetic fluid in a tunable optical device is worthy of investigation.

Objective α-Synuclein is critical to the pathogenesis of Parkinson’s disease (PD). Few studies examined the plasma levels of α-synuclein due to the exceptionally low level of α-synuclein in plasma compared with cerebrospinal fluid. We aimed to investigate plasma α-synuclein in patients with PD of different disease severity. Methods There were total 114 participants, including 80 patients with PD and 34 controls, in the study. Participants received a complete evaluation of motor and non-motor symptoms, including cognitive function. We applied immunomagnetic reduction-based immunoassay to measure plasma levels of α-synuclein. Results Plasma levels of α-synuclein were significantly higher in patients with PD compared with controls (median: 1.56 pg/mL, 95% CI 1.02 to 1.98 pg/mL vs 0.02 pg/mL, 95% CI 0.01 to 0.03 pg/mL; p<0.0001). Although there was a significant increase in plasma α-synuclein levels in PD patients with a higher Hoehn-Yahr (H-Y) stage, there was no correlation with motor symptom severity, as assessed by Unified Parkinson’s Disease Rating Scale part III scores, after confounders (age, gender, and disease duration) were taken into account. However, plasma α-synuclein levels were significantly higher in PD patients with dementia (PDD) than in PD patients with mild cognitive impairment (PD-MCI) or normal cognition (0.42 pg/mL, (95% CI 0.25 to 0.93) for PD with normal cognition; 1.29 pg/mL (95% CI 0.76 to 1.93) for PD-MCI and 4.09 pg/mL (95% CI 1.99 to 6.19) for PDD, p<0.01) and were negatively correlated with Mini-Mental State Examination scores (R²-adjusted=0.3004, p<0.001), even after confounder adjustment. Conclusions Our data suggest that plasma α-synuclein level correlates with cognitive decline but not motor severity in patients with PD. Plasma α-synuclein could serve as a surrogate biomarker for patients at risk of cognitive decline.

With a tunable refractive index, magnetic fluid can be applied to the development of adjustable optical devices. In this work, a magnetic-fluid-based optical switch is designed and characterized. The optical switch is formed by sealing magnetic fluid between two glass prisms. When a light is incident to one side of one of the prisms, a reflected light from the magnetic fluid film comes out from the same prism, whereas a transmitted light through the film emits from the other prism. It was found that the intensity ratio of the reflected light to the transmitted light can be manipulated by varying the external magnetic field strength. This implies that the light intensity can be switched between two paths. The switching efficiency also depends on the incident angle of a light into the prism. We then theoretically derive the incident-angle dependent switching efficiency to clarify relevant physical mechanisms.