This research work is focused on the development of an alternative method for manufacturing Wood Plastic Composite (WPC) panels based on Wood Veneers (WVs) and High-Density Polyethylene (HDPE) through compression molding, which enhances the physical properties, particularly, water absorption and moisture content. The aim of the present research was to develop alternative panels to replace commercial ones, which are heavily affected by hot, humid climates. In this context, the study began with the design process, which consisted of the collection and processing of primary material, production of the additional components necessary for the manufacturing process, determination of the WV ratio, and preparation of the samples. Thereafter, physical and mechanical tests were carried out on WPC, HDPE (control), commercial gypsum boards (GBs), plywood (PW), and medium density fiberboard (MDF) samples. The results indicate that the method applied to manufacture the WPC samples improved physical properties, achieving a water uptake of less than 4% in both proportions of replacement tested, in contrast to commercial panels, which reached values between 10% and 40%. In addition, a greater load capacity was achieved for lower thick elements.