Resources in deserts and sandy landscapes have potential for development, but existing surveys and sampling have not collected desert soil samples. As such, the geochemical background of these spaces remains unexplored due to the vastness and desolation of deserts. Therefore, researching the geochemical background values and geochemical baseline values of deserts is of long-term significance. Our research indicates that in addition to macrostructural environmental divisions, microelement geochemistry can also be used for geological unit zoning. In this paper, geochemical background and geochemical baseline values of 61 desert elements were calculated using the iterative method, frequency histograms method, and multifractal concentration-area method. It also analyzes the distribution characteristics of major, trace, and rare earth elements, and divides the 12 desert sand regions into different geochemical zones. This paper determines, for the first time, the geochemical background values of elements in Chinese deserts, filling the gap in the study of desert background values. By combining machine learning methods, different deserts have been divided into three geochemical zones. This research will greatly enhance our ability to interpret the geochemical distribution and evolutionary patterns of desert elements in China, and it has important scientific significance and practical value for desert research.