Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, the efficient treatment of inflammation has always been the hot topic in the research of medicine. In the past decades, as a potential biomaterial, stimuli‐responsive hydrogels have been a focus of attention for the inflammation treatment due to their excellent biocompatibility and design flexibility. Recently, thanks to the rapid development of nanotechnology and material science, more and more efforts have been made to develop safer, more personal and more effective hydrogels for the therapy of some frequent but tough inflammations such as sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, and ulcerative colitis. Herein, from recent studies and articles, the conventional and emerging hydrogels in the delivery of anti‐inflammatory drugs and the therapy for various inflammations are summarized. And their prospects of clinical translation and future development are also discussed in further detail.

The aging of population has resulted in a significant increase in the prevalence of rheumatoid arthritis (RA), which is a persistent and recurrent synovial inflammation caused by abnormal immune activation. Herein, the authors designed an inflammation‐triggered disassembly (ITD) nanoplatform by a supramolecular assembly method, which controls the decomposition and drug release through changes in cytokine concentrations and redox potentials during the onset of arthritis, and its dual‐targeted synergistic effect on collagen‐induced arthritis (CIA) rats resulted in higher cell death rate and immunosuppressive rate. Meanwhile, they propose the local dynamic dependent imaging (LDDI) technology to diagnose the disease status, which may produce corresponding changes with the fluctuation of inflammatory activity and improve the accuracy of dual‐target therapy by monitoring the synovial changes through in situ photoactivation of the second near infrared light (NIR‐II). Very importantly, histological analysis shows that ITD strategy relieved joint destruction and cartilage degeneration and its clinical score is similar to that of the healthy group. Their work provides an effective strategy for the early diagnosis and treatment of acute and chronic inflammation diseases, which can interfere to abnormal immune activation, rather than affecting the normal function of immune system.

With the intensification of aging issues, inflammatory orthopedic diseases almost occur in the majority of elderly people, which is becoming increasingly severe. Photoacoustic imaging (PAI) is a non‐invasive visualization technique for a clear diagnosis of the inflammation areas through detecting acoustic signals generated by the laser irradiation. The combination of “light input” and “acoustic output” provides unprecedented scalability as well as high penetration depth and resolution. This new imaging technology can also present more anatomical information and feedback status of inflammatory activity for the orthopedic diseases. Especially in inflammation imaging, this technology can effectively supplement current clinical imaging methods in diagnosis, staging, and monitoring of pathophysiological processes. With the rapid development of these new technologies, the goals of precise diagnosis, predictive regulation, and ultimately personalized treatment strategies are becoming increasingly realistic. Herein, this article introduces various orthopedic inflammations and related imaging technology applications. It covers the types of PA nanoprobes and their research progress in orthopedic inflammation, as well as the potential applications of PAI in various aspects. The review also discusses the recent researches and emerging translational applications of PAI in orthopedic inflammation, as well as the prospects and future development challenges of clinical transformation.

The performance optimization of photoluminescent (PL) materials is a hot topic in the field of applied materials research. There are many different crystal defects in photoluminescent materials, which can have a significant impact on their optical properties. The luminescent properties and chemical stability of materials can be effectively improved by adjusting lattice defects in crystals. We systematically studied the effect of doping ions on the energy transfer upconversion mechanism in different defect crystals by changing the matrix alkali metal ions. Meanwhile, the influence mechanism of crystal defect distribution on luminescence performance is explored by adjusting the ratio of Na–Li. The PL spectra indicate that changing the alkaline ions significantly affects the luminescence performance and efficiency of UCNPs. The change in ion radius leads to substitution or gap changes in the main lattice, which may alter the symmetry and strength of the crystal field around doped RE ions, thereby altering the UCL performance. Additionally, we demonstrated the imaging capabilities of the synthesized upconversion nanoparticles (UCNPs) in cellular environments using fluorescence microscopy. The results revealed that Na_0.9Li_0.1LuF₄–Yb, Er nanoparticles exhibited significantly enhanced fluorescence intensity in cell imaging compared to other compositions. We further investigated the mechanism by which structural defects formed by doping ions in UCNPs with different alkali metals affect energy transfer upconversion (ETU). This work emphasizes the importance of defect regulation in the ETU mechanism to improve the limitations of crystal structure on the luminescence performance and promote the future application of upconversion nanomaterials, which will provide important theoretical references for the exploration of high-performance luminescent materials in the future.

Infected diabetic foot ulcer (DFU) endangers patients through complex complications, which seriously increase the risk of amputation, prolongation of disability time and mortality, as well as bring a heavy burden to the medical system. This review focuses on the emerging biomedical engineering therapy of DFU and deeply analyzes the multiple pathogenic factors driving these intractable DFU wounds, including impaired angiogenesis, inflammatory disorder, microbial biofilm formation, and impaired immune response. It also synthesizes current clinical treatments and elaborates on their limitations that underscore the need for innovative solutions. The core of the review delves into recent breakthroughs in responsive antimicrobial biomaterials, emphasizing their stimuli‐triggered mechanisms that enable targeted drug release, enhanced bacterial eradication, and tissue regeneration promotion. Furthermore, it explores future trajectories for multifunctional biomaterials, envisioning integrated systems that combine antimicrobial, anti‐inflammatory, and pro‐healing properties to address the complex pathophysiology of infected DFU. By bridging current clinical challenges with biomaterial innovations, it can provide actionable insights for developing patient‐centric therapeutic strategies in biomedical engineering.