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Suicidal ideation, depressive symptoms, anxiety, and sleep disturbance remain difficult to manage in psychiatric populations, and intermittent theta‐burst stimulation (iTBS) has emerged as an accelerated, non‐invasive neuromodulation strategy for these outcomes. This meta‐analysis compares iTBS versus sham–iTBS across suicidal ideation, depression severity, anxiety severity, and sleep quality to guide clinical decision‐making. We systematically searched relevant electronic databases in accordance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Continuous outcomes were pooled as standardized mean differences (SMDs) with 95% confidence intervals using random‐effects inverse‐variance models in RevMan 5.4. Heterogeneity was assessed using I ² and χ ² statistics, and leave‐one‐out sensitivity analyses were performed. A p value < 0.05 was considered statistically significant. Six studies were included. iTBS significantly reduced suicidal ideation versus sham–iTBS (SMD = −0.51; 95% CI: −0.93 to −0.09; p = 0.02; I ² = 70%; n = 181 vs. 157), and the effect remained significant with lower heterogeneity after exclusion of Qin et al. ( p = 0.02; I ² = 29%). Depression severity improved with iTBS (SMD = −1.06; 95% CI: −1.64 to −0.48; p = 0.0003; I ² = 80%; n = 162 vs. 142), with heterogeneity decreasing to 24% after exclusion of Huang et al. Anxiety severity also improved (SMD = −0.68; 95% CI: −1.27 to −0.09; p = 0.02; I ² = 79%; n = 139 vs. 120), and heterogeneity decreased to 38% after exclusion of Huang et al. Sleep quality did not differ significantly between groups (SMD = −0.32; 95% CI: −0.98 to 0.34; p = 0.35; I ² = 67%; n = 75 vs. 49), based on two trials. iTBS was associated with a reduction in suicidal ideation compared with sham stimulation, but the small evidence base and between‐study heterogeneity limit certainty. Secondary analyses suggested improvements in depression and anxiety severity, whereas sleep quality did not differ between groups. Larger, standardized randomized controlled trials with longer follow‐up are needed to determine the magnitude and durability of any antisuicidal effect.

Chimeric antigen receptor (CAR) T cell therapy has shown remarkable efficacy in hematologic malignancies, yet its translation to solid tumors remains a fundamental challenge. Immunologically “cold” tumors, characterized by poor T cell infiltration, dense stromal barriers, and a profoundly immunosuppressive tumor microenvironment (TME), continue to resist conventional CAR-T cell approaches. Armored CAR-T cells engineered to secrete interleukin-18 (IL-18) represent a promising fourth-generation strategy designed to overcome these limitations. IL-18 operates at the interface of innate and adaptive immunity, driving M1 macrophage polarization, dendritic cell maturation, NK cell activation, and the induction of CXCL9/CXCL10 chemokine gradients that restore lymphocyte trafficking into tumor tissue. To guide the rational design of these constructs, bioinformatics pipelines play an increasingly central role. Multi-omics integration of transcriptomic, proteomic, and single-cell RNA sequencing data enables precise tumor antigen selection, epitope prediction, and structural optimization of CAR constructs using tools such as AlphaFold, RosettaDock, and NetMHCpan. In silico safety screening further evaluates off-target toxicity risks and cross-reactivity against healthy tissues. Controlled IL-18 delivery strategies, including NFAT-inducible promoters, SynNotch logic-gated systems, and Granzyme B-cleavable pro-IL-18 constructs, provide spatial and temporal safeguards against systemic hyperinflammation. Preclinical evidence from xenograft and syngeneic models demonstrates enhanced tumor control, sustained T cell persistence, and induction of endogenous anti-tumor immunity. This review synthesizes current evidence and highlights how bioinformatics-guided engineering of IL-18 armored CAR-T cells offers a translatable framework for converting cold tumors into immunologically responsive, therapeutically tractable targets.

Ectasia is the term used to describe the dilation of a coronary artery when its diameter is 1.5 times that of a normal artery. Myocardial bridge (MB) is a congenital coronary abnormality where a coronary artery segment tunnels across myocardial tissue, with coronary angiography (CAG) is the gold standard method for diagnosis. Here, we describe a case of an Afghan man who had both coronary artery ectasia and MB in the same segment of his left anterior descending artery (LAD).

The H5N1 influenza threat is a significant issue to the overall health of the population in the world, and it demands new approaches in vaccine development and implementation. The critical path forward is the development of universal vaccine platforms, which provide long-term cross-protection against various H5N1 strains. This type of vaccines, based on conserved regions of viruses, is necessary to provide long term immunity against antigenic variation. The future of vaccines should be based on the ability to generate both cellular and humoral immunity and provide the greatest level of protection against a variety of viral variants. It is also crucial that agile manufacturing capacities are established, which can swiftly expand the production of vaccines to satisfy the demand in the world in the case of an influenza outbreak. The technology of mRNA vaccines, viral vectors, or microneedle patches can be adapted to novel strains rapidly and responds effectively to the situation when rapid and effective responses are required. Also, fair global distribution policies can be crucial to make it possible to make vaccines available to the population of low- and middle-income countries. The international response needs to focus on equity, whereby inequality in access to vaccines is minimized. This has been the ultimate solution of combining universal vaccines, cross-protection, agile production, and equity over the world to reduce the threat of H5N1 pandemic. By developing these measures, the world community can be more ready to the upcoming outbreak of influenza, and access to a vaccine can be timely, extensive, and efficient.