Dendrimers are well‐defined nanoparticles, which have far‐reaching application in the field of chemistry. Many efforts have been devoted to development of dendrimer due to thier unique structure and various properties and broad application. It helps in varieties of purposes as a catalyst in drug delivery and drug design. The topological descriptor analyze the structure–property relationship of chemical compounds. In this paper, some numerical expressions have been obtained to understand the behavioral pattern of chiral polyamidoamine (PAMAM) dendrimer and PAMAM anthracene moieties dendrimer. The analytical expression has been plotted and compared with varieties of indices to show how it varies between each indices.