In recent years, much research has focused on using machine learning (ML) for disease prediction based on gene expression (GE) data. However, many diseases have received considerable attention, whereas some, including Alzheimer’s disease (AD), have not, perhaps due to data shortage. The present work is intended to fill this gap by introducing a symmetric framework to predict AD from GE data, with the aim to produce the most accurate prediction using the smallest number of genes. The framework works in four stages after it receives a training dataset: pre-processing, gene selection (GS), classification, and AD prediction. The symmetry of the model is manifested in all of its stages. In the pre-processing stage gene columns in the training dataset are pre-processed identically. In the GS stage, the same user-defined filter metrics are invoked on every gene individually, and so are the same user-defined wrapper metrics. In the classification stage, a number of user-defined ML models are applied identically using the minimal set of genes selected in the preceding stage. The core of the proposed framework is a meticulous GS algorithm which we have designed to nominate eight subsets of the original set of genes provided in the training dataset. Exploring the eight subsets, the algorithm selects the best one to describe AD, and also the best ML model to predict the disease using this subset. For credible results, the framework calculates performance metrics using repeated stratified k-fold cross validation. To evaluate the framework, we used an AD dataset of 1157 cases and 39,280 genes, obtained by combining a number of smaller public datasets. The cases were split in two partitions, 1000 for training/testing, using 10-fold CV repeated 30 times, and 157 for validation. From the testing/training phase, the framework identified only 1058 genes to be the most relevant and the support vector machine (SVM) model to be the most accurate with these genes. In the final validation, we used the 157 cases that were never seen by the SVM classifier. For credible performance evaluation, we evaluated the classifier via six metrics, for which we obtained impressive values. Specifically, we obtained 0.97, 0.97, 0.98, 0.945, 0.972, and 0.975 for the sensitivity (recall), specificity, precision, kappa index, AUC, and accuracy, respectively.

The increase of security threats and hacking the computer networks are one of the most dangerous issues should treat in these days. Intrusion Detection Systems (IDSs), are the most appropriate methods to prevent and detect the attacks of networks and computer systems. This study presents several techniques to discover network anomalies using data mining tasks, Machine learning technology and dependence of artificial intelligence techniques. In this research, the smart hybrid model was developed to explore any penetrations inside the network. The model divides into two basic stages. The first stage includes the Genetic Algorithm (GA) in selecting the characteristics with depends on a process of extracting, Discretize And dimensionality reduction through Proportional K-Interval Discretization (PKID) and Fisher Linear Discriminant Analysis (FLDA) on respectively. At the end of the first stage combining Naïve Bayes classifier (NB) and Decision Table (DT) using NSL-KDD data set divided into two separate groups for training and testing. The second stage completely depends on the first stage outputs (predicted class) and reclassified with multilayer perceptrons using Deep Learning4J (DL) and the use of algorithm Stochastic Gradient Descent (SGD). In order to improve the performance in terms of the accuracy in classification of penetrations, raising the average of discovering and reducing the false alarms. The comparison of the proposed model and conventional models show the superiority of the proposed model and the previous conventional hybrid models. The result of the proposed model is 99.9325 of classification accuracy, the rate of detection is 99.9738 and 0.00093 of false alarms

Linear associative memories (LAM) have been intensely used in the areas of pattern recognition and parallel processing for the past two decades. Application of LAM to nonlinear parameter estimation, however, has only been recently attempted. The process consists in converting the nonlinear function in the parameters into a set of linear algebraic equations. The nature of the linearized system and the factors influencing the accuracy of the parameter estimates have not yet been fully investigated. In this paper, LAM is applied to a nonlinear five-parameter model of the neuron. Ill-conditioning, which is often exhibited in LAM, is treated with the method of regularization as well as by the singular value decomposition (SVD). Simulation results indicate that the parameters estimated by LAM exhibit a remarkable robustness against additive white noise in comparison with the classical gradient optimization technique. Moreover, it is shown that regularization can be superior to SVD under certain conditions. Our results suggest that LAM can be used both as a noise reduction technique and as a stand-alone nonlinear parameter estimation algorithm. The comparison between LAM and a gradient technique show that, for this estimation problem, the LAM method can give more reliable estimates. Further improvements in estimation quality may still be achieved by the use of other forms of regularizing functions.

Gene expression (GE) classification is a research trend as it has been used to diagnose and prognosis many diseases. Employing machine learning (ML) in the prediction of many diseases based on GE data has been a flourishing research area. However, some diseases, like Alzheimer’s disease (AD), have not received considerable attention, probably owing to data scarcity obstacles. In this work, we shed light on the prediction of AD from GE data accurately using ML. Our approach consists of four phases: preprocessing, gene selection (GS), classification, and performance validation. In the preprocessing phase, gene columns are preprocessed identically. In the GS phase, a hybrid filtering method and embedded method are used. In the classification phase, three ML models are implemented using the bare minimum of the chosen genes obtained from the previous phase. The final phase is to validate the performance of these classifiers using different metrics. The crux of this article is to select the most informative genes from the hybrid method, and the best ML technique to predict AD using this minimal set of genes. Five different datasets are used to achieve our goal. We predict AD with impressive values for MultiLayer Perceptron (MLP) classifier which has the best performance metrics in four datasets, and the Support Vector Machine (SVM) achieves the highest performance values in only one dataset. We assessed the classifiers using seven metrics; and received impressive results, allowing for a credible performance rating. The metrics values we obtain in our study lie in the range [.97, .99] for the accuracy (Acc), [.97, .99] for F1-score, [.94, .98] for kappa index, [.97, .99] for area under curve (AUC), [.95, 1] for precision, [.98, .99] for sensitivity (recall), and [.98, 1] for specificity. With these results, the proposed approach outperforms recent interesting results. With these results, the proposed approach outperforms recent interesting results.

Now-a-days, social media platforms enable people to continuously express their opinions and thoughts about different topics. Monitoring and analyzing the sentiments of people is essential for governments and business organizations to better understand people’s feelings and thoughts. The Coronavirus disease 2019 (COVID-19) has been one of the most trending topics on social media over the last two years. Consequently, one of the preventative measures to control and prevent the spread of the virus was vaccination. A dataset was formed by collecting tweets from Twitter for over a month from November 13th to December 31st, 2021. After data cleaning, the tweets were assigned a positive, negative, or neutral label using a natural language processing (NLP) sentiment analysis tool. This study aims to analyze people's public opinion towards the vaccination process against COVID-19. To fulfil this goal, an ensemble model based on deep learning (LSTM-2BiGRU) is proposed that combines long short-term memory (LSTM) and bidirectional gated recurrent unit (BiGRU). The performance of the proposed model is compared to five traditional machine learning models, two deep learning models in addition to state-of-the-art models. By comparing the results of the models used in this study, the results reveal that the proposed model outperforms all the machine and deep learning models employed in this work with a 92.46% accuracy score. This study also shows that the number of tweets that involve neutral, positive, and negative sentiments is 517496 (37%) tweets, 484258 (34%) tweets, and 409570 (29%) tweets, respectively. The findings indicate that the number of people carrying neutral sentiments towards COVID-19 immunization through vaccines is the highest among others.

Caching plays an important role in reducing latency and increasing the overall performance of fog computing systems. With the rise of the Internet of Things (IoT) and edge computing, fog computing has become an essential paradigm for addressing the challenges related to latency-sensitive and bandwidth-intensive applications. The integration of Information-Centric Networking (ICN) and Fog Computing (ICN-Fog) has emerged as a promising solution for meeting the demands of low-latency and high-throughput applications in rapidly growing IoT devices. A step was taken by ICN-Fog to reduce latency and achieve higher data communication and information gathering for fog computing. Using Artificial Intelligence (AI) methods, the Firefly Optimization Technique was introduced as an effective optimization algorithm to enhance the caching technique. In this study, we aim to improve several performance metrics, such as the cache hit ratio, internal link load, and average query duration. To achieve these enhancements, we propose a unique solution inspired by the Firefly Optimization Technique. This technique applies to the ICN-Fog caching model, which was utilized to intelligently determine cache placement and network topology adaptations. CloudSim was employed to execute a simulation of the proposed strategy. The results of the experiments suggest that the Multi-Objective Firefly Algorithm (MOFA) outperforms the compared algorithms in terms of both efficiency and effectiveness in identifying the optimal caching technique.