Farmed mussels accumulate contaminants from their production environment rather than releasing them into water. This study reveals potential health risks associated with selenium, cadmium, mercury, and lead resulting from the consumption of mussels (Mytilus galloprovincialis) cultured along the coasts of Türkiye and Bulgaria. The concentrations of Se and toxic trace metals were measured by inductively coupled plasma mass spectrometry (ICP-MS). The detection limits (LOD) were 0.100, 0.015, 0.025, and 0.180 µg/kg for Se, Cd, Hg, and Pb, respectively. The mean Se concentrations were between 1.305 and 1.957 µg/g, and toxic metals were below the maximum limits. Due to Turkish and Bulgarian consumers’ limited mollusk consumption, mussels could only provide a maximum of 7.35% of the daily Se need. THQ and TTHQ of Se, Cd, and methyl-Hg were below 1, indicating that farmed mussels were safe for consumption. Percent PTWI values were calculated only for Cd and MeHg, as the PTWI value for Pb was discarded by the authorities and not determined for Se. Accordingly, weekly mussel consumption did not pose any risks. The margin of exposure approach was used to evaluate Pb intake. MOE-SBP and MOE-NE were significantly higher than 10, designating no significant health risks. Long-term consumption of mussels also does not pose a carcinogenic risk regarding the TR index calculated between 10⁻⁵ and 10⁻⁶ for Pb. Positive HBV_Se (10.13–37.27) indicated that Se in mussels overcame Hg-related potential health concerns. Consequently, mussels grown in Türkiye and Bulgaria did not pose a risk for human consumption, based on current risk analysis methods.