Sepsis refers to a potentially life-threatening situation where the immune system of the human body has an extreme response to an infection. In the presence of underlying comorbidities, the situation can become even worse and result in death. Employing unsupervised machine learning techniques, such as clustering, can assist in providing a better understanding of patient phenotypes by unveiling subgroups characterized by distinct sepsis progression and treatment patterns. More concretely, this study introduces M-ClustEHR, a clustering approach that utilizes medical data of multiple modalities by employing a multimodal autoencoder for learning comprehensive sepsis patient representations. M-ClustEHR consistently outperforms traditional clustering approaches in terms of several internal clustering performance metrics, as well as cluster stability in identifying phenotypes in the sepsis cohort. The unveiled patterns, supported by existing medical literature and clinicians, highlight the importance of multimodal clustering for advancing personalized sepsis care.

The impacts of climate change on mental health are starting to be recognized and may be exacerbated for populations at disproportionate risk of health impacts or inequalities, including some people living in low- and middle-income countries, children, indigenous populations, and people living in rural communities, among others. Here, we conduct a rapid scoping review of reviews to summarize the research to date on climate impacts on the mental health of populations at disproportionate risk. This review highlights the direct and indirect effects of climate change, the common mental health issues that have been studied related to climate events, and the populations that have been studied to date. This review outlines key gaps in the field and important research areas going forward. These include a need for more systematic methodologies, with before-and-after comparisons or exposure/non-exposure group comparisons and consistent mental health outcome measurements that are appropriately adapted for the populations being studied. Further research is also necessary in regard to the indirect effects of climate change and the climate effects on indigenous populations and populations with other protected and intersecting characteristics. This review highlights the key research areas to date and maps the critical future research necessary to develop future interventions.

Background: With the ongoing, rapid advances in Deep Learning (DL), such solutions can now detect medical conditions even invisible to the human eye. In this direction, efforts have been made to develop DL algorithms that diagnose paroxysmal atrial fibrillation (PAF) from electrocardiogram (ECG) signals in sinus rhythm (SR). However, many of the available approaches function as “black boxes”, with physicians unable to understand and trust their predictions. Purpose: To train a DL model to detect PAF patients while in SR and apply an algorithm that interprets and visualises its decisions. Methods: We obtained ECG samples from PAF and non-PAF patients during SR, from the PAF Prediction Challenge Database. After discarding unannotated samples and augmenting the sample size (by dividing each signal into 30-second segments), we split the whole dataset into a train (68%), a validation (16%) and a test (16%) set. No pair of samples belonging to different sets originated from the same patient. We trained the InceptionTime neural network on the train/validation sets and tested on the “unseen” test set after “hiding” the correct answers. Its performance was evaluated with the following metrics: Accuracy, f1-score, precision and recall (sensitivity). After repeating this process 20 times, we obtained a distribution for each score. Finally, we adjusted the Grad-CAM interpretation algorithm to our data and used it to visualise the areas perceived as important by the model. Results: After pre-processing, 4,080, 30-second, two-lead ECG signals were allocated to the train set, 960 to the validation and 960 to the test set. Each subset contained an equal number of PAF and non-PAF samples. After repeated training and testing, we obtained a median accuracy of 0.84 (interquartile range, IQR: 0.66–0.88), an f1-score of 0.82 (IQR: 0.68–0.88) and a median precision and recall equal to 0.93 (IQR: 0.67–0.99) and 0.77 (IQR: 0.68–0.93), respectively. The Grad-CAM technique highlighted the ECG areas of interest that led to each decision. We selected and present both PAF-positive and -negative samples, perceived either correctly or falsely. Interestingly, correct model decisions tend to focus on the P-wave, while false ones fixate on other regions. Conclusions: Although a pilot study with considerable limitations (small sample size, disregard of possible confounding due to comorbidities or other factors), this work shows how DL can be employed to distinguish between PAF and non-PAF patients from SR ECG samples, and confirms the potential of DL-enabled approaches to offer novel diagnostic capabilities. Most importantly, our effort provides a comprehensible, visual interpretation of the model's decisions. Demystifying DL behaviour can, not only improve such efforts by explaining false decisions, but also cultivate trust among clinicians and, possibly, point out directions for future research, since we can now see through the magnifying lens of a neural network. Funding Acknowledgement: Type of funding sources: None.