Optical communications providing huge capacity and low latency remain vulnerable to a range of attacks. In consequence, encryption at the optical layer is needed to ensure secure data transmission. In our previous work, we proposed LightPath SECurity (LPSec), a secure cryptographic solution for optical transmission that leverages stream ciphers and Diffie–Hellman (DH) key exchange for high-speed optical encryption. Still, LPSec faces limitations related to key generation and key distribution. To address these limitations, in this paper, we rely on Quantum Random Number Generators (QRNG) and Quantum Key Distribution (QKD) networks. Specifically, we focus on three meaningful scenarios: In Scenario A, the two optical transponders (Tp) involved in the optical transmission are within the security perimeter of the QKD network. In Scenario B, only one Tp is within the QKD network, so keys are retrieved from a QRNG and distributed using LPSec. Finally, Scenario C extends Scenario B by employing Post-Quantum Cryptography (PQC) by implementing a Key Encapsulation Mechanism (KEM) to secure key exchanges. The scenarios are analyzed based on their security, efficiency, and applicability, demonstrating the potential of quantum-enhanced LPSec to provide secure, low-latency encryption for current optical communications. The experimental assessment, conducted on the Madrid Quantum Infrastructure, validates the feasibility of the proposed solutions.