Pieter P.R.N. D'Hooghe

Dr. Pieter P.R.N. D'Hooghe


Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 August 2019 in British Journal of Sports Medicine
Verified
Journal Article
Open access
PDF file
PDPieter P.R.N. D'Hooghe
Pieter P.R.N. D'Hooghe
AGAlberto Grassi
Alberto Grassi
KAKhalid Alkhelaifi
Khalid Alkhelaifi
JCJames Calder
James Calder
TBThomas Paulus Alouisius Baltes
Thomas Paulus Alouisius Baltes
JEJan Ekstrand
Jan Ekstrand
Objectives To evaluate time to return to play following surgical stabilisation of isolated unstable syndesmosis injuries in a cohort of professional male football players. Methods All professional football players undergoing surgery for isolated unstable syndesmosis injury (West Point grade ≥IIB) at a specialised Orthopaedic and Sports Medicine Hospital were followed up until return to play (minimum ≥6 months). Players with a stable syndesmosis, injuries older than 6 weeks, concomitant medial or lateral malleolar fracture or previous ankle surgery were excluded. During rehabilitation, time required to return to sports-specific rehabilitation, team training and first match play, were recorded. Results Between January 2012 and December 2017, a total of 110 male professional football players were included. The mean time required to begin on field rehabilitation was 37±12 days, while the mean time to return to team training was 72±28 days. The first official match was played on average 103±28 days postoperatively. Multivariable analysis revealed that the severity of injury, the concomitant presence of talar cartilage injury and the age of the player were significantly associated (p<0.00001) with time to return to on field rehabilitation, team training and match play. Conclusion In this cohort of professional football players, surgical stabilisation of isolated unstable syndesmosis injuries (West Point grade ≥IIB) allowed for relatively quick return to play. High grade injury (West Point grade III), concomitant cartilage injury and greater age were associated with longer return to play times. Level of evidence Longitudinal observational cohort study (level II).

30 July 2019 in British Journal of Sports Medicine
Verified
Journal Article
Closed access
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AGAlberto Grassi
Alberto Grassi
GRGuendalina Rossi
Guendalina Rossi
PDPieter P.R.N. D'Hooghe
Pieter P.R.N. D'Hooghe
RARandeep Aujla
Randeep Aujla
MMMassimiliano Mosca
Massimiliano Mosca
SZStefano Zaffagnini
Stefano Zaffagnini
Objective: To evaluate the time to return to playing following acute Achilles tendon rupture (ATR) and surgical repair in professional male football (soccer) players.Methods: Professional male football (soccer) players who sustained an ATR and underwent surgical repair were identified through internet-based injury reports from January 2008 to August 2018. Only League 1 and 2 players with injuries who had at least 1 year of follow-up from the search date were included. Injury history and time to return to play were retrieved from the public platformtransfermarkt.com. For athletes who competed for at least two seasons after returning to play, re-ruptures and number of matches played were reported.Results: 118 athletes (mean age 27.2±7.2 years) were included. 113 (96%) returned to unrestricted practice after a mean of 199±53 days, with faster recovery in players involved in national teams. Return to competition was after a mean of 274±114 days. In the 76 athletes with at least two seasons of follow-up, 14 (18%) did not compete at the pre-injury level during the two seasons following the index injury. Six players (8%) sustained a re-rupture within the first two seasons after return to play; four re-ruptures were in footballers who returned to play 30 years and re-ruptures had higher odds ratios of not returning to the same level of play.Conclusions: 96% of professional male football players who underwent surgery to repair an ATR returned to unrestricted practice and then competition after an average time of 7 and 9 months, respectively. However, 18% did not return to the same level of play within the two seasons following their return, with a higher risk in those experiencing a re-rupture.

1 July 2021 in Orthopaedic Journal of Sports Medicine
Verified
Journal Article
Open access
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AAAhmed Khalil Attia
Ahmed Khalil Attia
TTTarek Taha
Tarek Taha
KMKarim Mahmoud
Karim Mahmoud
KHKenneth J. Hunt
Kenneth J. Hunt
SLSameh A. Labib
Sameh A. Labib
PDPieter P.R.N. D'Hooghe
Pieter P.R.N. D'Hooghe
Background: Nearly 20% of acute ankle sprains progress to chronic lateral ankle instability that requires surgical intervention. In recent years, there has been a growing interest in arthroscopic Broström techniques as an alternative to open surgery. Purpose: To review the most up-to-date evidence comparing the outcomes of open and arthroscopic Broström procedures for chronic lateral ankle instability. Study Design: Systematic review; Level of evidence, 3. Methods: This review was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Relevant comparative studies in English up to May 2020 were identified. The primary outcomes were (1) functional scores (Karlsson Ankle Function Score and American Orthopaedic Foot & Ankle Society [AOFAS] score) and (2) the 10-point visual analog scale (VAS) score for pain. The secondary outcomes were differences in (1) postoperative anterior drawer and talar tilt, (2) surgical time and complication rate, and (3) time to return to sports and weightbearing. Results: A total of 408 patients in 8 studies met the inclusion criteria. Of these, 193 (47.3%) patients underwent open surgery, while 215 (52.7%) patients underwent arthroscopic surgery. There were significant differences between the open and arthroscopic repair groups in mean 6-month AOFAS scores (82.4 vs 92.25, respectively; mean difference [MD], 11.36; 95% CI, 0.14-2.56; I 2 = 90%; P = .03), 1-year AOFAS scores (80.05 vs 88.6; MD, –11.96; 95% CI, –21.26 to –2.76; I 2 = 82%; P = .01), 6-month VAS scores (1.7 vs 1.4; MD, –0.38; 95% CI, –0.54 to –0.21; I 2 = 78%; P < .001), and 1-year VAS scores (2.05 vs 1.45; MD, 0.31; 95% CI, 0.09-0.54; I 2 = 0%; P < .001). The mean time to weightbearing was 14.25 and 9.0 weeks in the open and arthroscopic repair groups, respectively (MD, 1.89; 95% CI, 1.24-2.54; I 2 = 99%; P < .001). There were no statistically significant differences in the remaining outcomes evaluated. Conclusion: While technically more demanding, arthroscopic Broström was superior to open Broström-Gould surgery in postoperative AOFAS scores, VAS pain scores, and time to return to weightbearing. The operative time, complication rate, talar tilt, and anterior drawer tests were excellent and statistically comparable. Long-term clinical trials are required before recommending arthroscopic Broström as the new gold standard.

1 February 2022 in Journal of ISAKOS
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Journal Article
Open access
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GVGustavo Vinagre
Gustavo Vinagre
FCFlávio Cruz
Flávio Cruz
KAKhalid Alkhelaifi
Khalid Alkhelaifi
PDPieter P.R.N. D'Hooghe
Pieter P.R.N. D'Hooghe
The prevalence of isolated meniscal injuries in children and adolescents is low; however, we see an increase mainly due to intensified sports-related activities at an early age. A meniscal repair should be attempted whenever possible as children present with increased meniscal healing potential. The diagnosis and management of meniscal tears involve both patient factors and tear characteristics: size, anatomical location and associated injuries. Special attention should be given to the feature of discoid menisci and related tears as they require a specific management plan. This state-of-the-art review highlights the most recent studies on clinical evaluation, surgical techniques, tips and tricks, pitfalls, outcomes, return-to-sports, geographical differences and future perspectives related to meniscal injuries in children and adolescents.

13 June 2022 in Knee Surgery, Sports Traumatology, Arthroscopy
Verified
Journal Article
Open access
PDF file
PDPieter P.R.N. D'Hooghe
Pieter P.R.N. D'Hooghe
AGAlberto Grassi
Alberto Grassi
FVFrancesco Della Villa
Francesco Della Villa
KAKhalid Alkhelaifi
Khalid Alkhelaifi
EPEmmanouil Papakostas
Emmanouil Papakostas
SZStefano Zaffagnini
Stefano Zaffagnini
Purpose: To analyze the MRI features, in particular bone bruises pattern, of Anterior Cruciate Ligament (ACL) injured footballers, and to correlate them with the characteristics of injury mechanism and situation obtained from direct video footage.Methods: Nineteen professional football (soccer) players that sustained ACL injury while playing during an official match of First League Championship were included in the study. The video of injury was obtained from the Television broadcast. Knee Magnetic Resonance (MRI) was obtained within 7 days from the injury. BB and meniscal lesions were analyzed on MRI, while a video‐analysis of mechanisms of ACL injury and injury dynamic were assessed from the videos.Results: The most commonly involved Bone Bruise areas in the knee were the Posterior Lateral Tibial Plateau (LTp) in 16 cases (84%) and the Central Lateral Femoral Condyle (LFc) in 11 cases (58%). Three patients (16%) had bone bruise in the Posterior Medial Tibial Plateau (MTp) while none (0%) had bone bruise in the Medial Femoral Condyle. Based on the bone bruise pattern, 11 (58%) had simultaneous LFc and LTp and were defined “Typical” while 8 (42%) had other locations or no bone bruise and were defined “Atypical”. 9 out of 11 injuries (82%) of athletes with “Typical” pattern occurred with a “Pivoting” action”, in contrast to only 1 case (12%) in those with “Atypical” bone bruise pattern (p = 0.0055).The most common situational mechanism pattern on video analysis was “pressing” (n = 7) accounting for the 47% of the “indirect” ACL injuries. In terms of movement pattern, ten injuries (52%) occurred during a “Pivoting” movement (7 pressing, 1 dribbling, 1 tackled, 1 goalkeeping), whereas the remaining were classified as “Planting” in four cases, “Direct Blow” in four cases and “Landing”.Conclusion: A well‐defined and consistent bone bruise pattern involving the posterior tibial plateau and central femoral condyle of lateral compartment is present in footballers that sustained non‐contact and indirect ACL injuries during pivoting with sudden change of direction/deceleration, while heterogeneous patterns were present in those with direct contact or injury mechanisms involving high horizontal velocity.Level of evidence: Level IV.

12 December 2022 in Cells
Verified
Journal Article
Open access
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NANoor Al-Maslamani
Noor Al-Maslamani
RORachel of Oldershaw
Rachel of Oldershaw
STSimon R. Tew
Simon R. Tew
JCJude Curran
Jude Curran
PDPieter P.R.N. D'Hooghe
Pieter P.R.N. D'Hooghe
HHHenning F. Horn
Henning F. Horn
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro. The expansion process provides the benefit of generating a large number of cells required for implantation; however, during the expansion these cells de-differentiate and lose their chondrocyte phenotype. In this review we focus on examining the de-differentiation phenotype from a mechanobiology and biophysical perspective, highlighting some of the nuclear mechanics and chromatin changes in chondrocytes seen during the expansion process and how this relates to the gene expression profile. We propose that manipulating chondrocyte nuclear architecture and chromatin organization will highlight mechanisms that will help to preserve the chondrocyte phenotype.