Lithium-ion battery systems are a core component for electric mobility, which has become increasingly important in the last decade. The rising number of new manufacturers and model variants also increases competitive pressure. Competition is shortening development times. At the same time, the range of technology options for batteries is growing steadily. Fast and well-founded concept development is becoming even more essential in this increasingly complex environment. For this purpose, various model-based systems engineering (MBSE) methods are analyzed and evaluated. Based on this, the battery modeling framework is derived and described, tailored to the needs of battery development. The validation of the methodological approach is demonstrated by the simulation workflow from an electrical cell characterization to the thermal evaluation of different cooling methods.