In the present study, the feasibility to achieve localized induction heating and debonding of multi-material composite structures is assessed in testing coupons prepared by Automated Fiber Placement (AFP) and extrusion-based additive manufacturing (AM) technologies. Nano-compounds of Polyether-ketone-ketone (PEKK) with iron oxide nanoparticles acting as electromagnetic susceptors have been processed in a parallel co-rotating twin-screw extruder to produce filament feedstock for extrusion-based AM. The integration of nanocomposite interlayers as discrete debonding zones (DZ) by AFP-AM manufacturing has been investigated for two types of sandwich-structured laminate composites, i.e., laminate-DZ-laminate panels (Type I) and laminate-DZ-AM gyroid structures (Type II). Specimens were exposed to an alternating magnetic field generated by a radio frequency generator and a flat spiral copper induction coil, and induction heating parameters (frequency, power, heating time, sample standoff distance from coil) have been investigated in correlation with real-time thermal imaging to define the debonding process window without compromising laminate quality. For the optimized process parameters, i.e., 2–3 kW generator power and 20–25 mm standoff distance, corresponding to magnetic field intensities in the range of 3–5 kA m⁻¹, specimens were effectively heated above PEKK melting temperature, exhibiting high heating rates within the range of 5.3–9.4 °C/s (Type I) and 8.0–17.5 °C/s (Type II). The results demonstrated that localized induction heating successfully facilitated debonding, leading to full unzipping of the debonding zones in both laminate structures. Further insight on PEKK nanocomposites debonding performance was provided by thermal, morphological characterization and non-destructive inspection via X-ray micro-computed tomography at different processing stages. The developed framework aims to contribute to the development of rapid, on-demand joining, repair and disassembly technologies for thermoplastic composites, towards more efficient maintenance, repair and overhaul operations in the aviation sector and beyond.