Introduction. Over the past 5 years, signifi cant progress has been achieved in the treatment of patients with Ph-negative acute lymphoblastic leukemia (ALL). Treatment results were compared between two protocols of the Russian multicenter studies «ALL-2009» and «ALL-2016», in which multicomponent high-dose consolidation was not used. The principle of continuity of treatment was observed with modifi cation of doses of cytostatic drugs depending on the depth of cytopenia.Aim – to compare the 5-year results of two studies and to determine the factors of unfavorable prognosis in the treatment of patients with ALL.Materials and methods. The studies were performed from April 2009 to April 2016 (ALL-2009) and from April 2016 to September 2021 (ALL-2016), and 596 patients were included: 330 in ALL-2009 and 266 in ALL-2016. The analysis was performed in March 2022. The median age of patients in ALL-2009 was 28 years (15–55), in ALL-2016 – 32.5 years (18–55). Cytogenetic studies were performed in 242 patients in ALL-2009 (73.3 %) and 236 patients in ALL-2016 (88.7 %). Patients in the ALL-2016 protocol underwent a centralized assessment of minimal residual disease (MRD) by fl ow cytometry on protocol +70 day (after completion of two induction phases), +133 and +190 days. Transplantation of allogeneic stem hematopoietic cells was performed in 7 % of patients in ALL-2009 and in 9 % in ALL-2016.Results. Overall, relapse-free survival (OS, RFS) and the probability of relapse for a period of 3 years from the moment of inclusion of patients in a particular study were 59 %, 63 % and 23 % for ALL-2009, and for ALL-2016 – 64 %, 59 % and 22 %, respectively. For patients with B-cell precursor ALL, two cytogenetic risk groups were formed, in which long-term survival rates differed signifi cantly: the standard group (hyperploid set of chromosomes and normal karyotype) – OS 63 %, RFS 70 %, and high cytogenetic risk (any abnormal karyotype, except for hyperploidy) – OS 49 %, RFS 52 % (р = 0.001, р = 0.0014). In T-ALL, cytogenetic markers had no prognostic value, but the immunophenotype of early T-cell precursor turned out to be an important predictor of poor prognosis (the probability of relapse was 52 % compared with 15 % for all other immunophenotypic variants). According to the results of centralized monitoring of MRD, it was determined that for B-cell precursor ALL, the signifi cant negative factors are the high cytogenetic risk group and positive MRD status at +70 day, and for T-cells, the early immunophenotype and positive MRD status at +133 day.

3D graphics is a kind of computer graphics which has absorbed a lot from the vector and raster computer graphics. It is used in interior design projects, architectural projects, advertising, while creating educational computer programs, movies, visual images of parts and products in engineering, etc. 3D computer graphics allows one to create 3D scenes along with simulation of light conditions and setting up standpoints.

The authors describe the method improving effective management of technological processes of the mining enterprise taking into account analysis and data processing for technogenic cycles at enterprise operation. The authors offer a system for accounting technogenic process cycles, algorithms on management of stability of system, and give the definition of the technogenic cycle concept. The technique of matrix representation and analysis of technogenic factors of production, which can be used also for the analysis of enterprise processes from the point of view of an assessment of their deviation from the required parameters directly defining production quality is also given.

The article presents a case study on contamination of the environment by industrial plants situated inside an inhabited locality. Such situation is typical for the city of Vladikavkaz where Electrozinc Metallurgical Plant, an environmentally hazardous production facility, is situated within the limits of the city. For well-timed recording, analysis and prevention of hazardous production emissions, an information-and-analysis system has been created and encompasses both the mentioned plant and other factories within the city. The layered structure of the system and interoperation of subsystems and control units, including the unit for coordination and control of subsystem interoperation, engineered by the present authors, is described. The programs and databases are accustomed to hardware of permanent models of geo-information systems and are compatible with the available software support. The application of the proposed system in monitoring and analysis of production-induced contamination in Vladikavkaz as a consequence of metallurgical plant operation may contribute to balancing environmental situation across the entire Republic of North Ossetia – Alania. Added by specific details of test objects, the software support becomes applicable in any geographical region of the Russian Federation.

BCR/ABL, делеции IKZF и FLT3-ITD как мишени для лечения рецидивов и рефрактерных форм острых В-лимфобластных лейкозов: блинатумомаб в сочетании с ингибиторами тирозинкиназ и ATRABCR/ABL, IKZF deletions and FLT3-ITD as the targets for relapsed/refractory B-cell acute lymphoblastic leukemia treatment: Blinatumomab combined with Tyrosine kinase inhibitors and ATRA