hafiz Ahmed

Dr. hafiz Ahmed


Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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15 July 2017 in Oncotarget
Verified
Journal Article
Open access
PDF file
PGPrasun Guha
Prasun Guha
EKEngin Kaptan
Engin Kaptan
PGPadmaja Gade
Padmaja Gade
DKDhananjaya V. Kalvakolanu
Dhananjaya V. Kalvakolanu
HAhafiz Ahmed
hafiz Ahmed
Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1 Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1

1 January 2015 in Clinical Medicine Insights: Oncology
Verified
Journal Article
Open access
HAhafiz Ahmed
hafiz Ahmed
DADina AlSadek
Dina AlSadek
Interactions between two cells or between cell and extracellular matrix mediated by protein–carbohydrate interactions play pivotal roles in modulating various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding lectin family, is involved in fibrosis as well as cancer progression and metastasis, but the detailed mechanisms of its functions remain elusive. This review discusses its structure, carbohydrate-binding properties, and involvement in various aspects of tumorigenesis and some potential carbohydrate ligands that are currently investigated to block galectin-3 activity.

26 March 2014 in Breast Cancer Research and Treatment
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Journal Article
Closed access
PDF file
PGPrasun Guha
Prasun Guha
GBGargi Bandyopadhyaya
Gargi Bandyopadhyaya
SPSwamy K. Polumuri
Swamy K. Polumuri
SCSaranya Chumsri
Saranya Chumsri
PGPadmaja Gade
Padmaja Gade
HAhafiz Ahmed
hafiz Ahmed

Verified
Journal Article
Open access
PDF file
RARakin Ahmed
Rakin Ahmed
KAKhairul Anam
Khairul Anam
HAhafiz Ahmed
hafiz Ahmed
Galectin-3 (Gal3) is one of the most studied members of the galectin family that mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Since Gal3 is pro-inflammatory, it is involved in many diseases that are associated with chronic inflammation such as cancer, organ fibrosis, and type 2 diabetes. As a multifunctional protein involved in multiple pathways of many diseases, Gal3 has generated significant interest in pharmaceutical industries. As a result, several Gal3-targeting therapeutic drugs are being developed to address unmet medical needs. Based on the PubMed search of Gal3 to date (1987–2023), here, we briefly describe its structure, carbohydrate-binding properties, endogenous ligands, and roles in various diseases. We also discuss its potential antagonists that are currently being investigated clinically or pre-clinically by the public and private companies. The updated knowledge on Gal3 function in various diseases could initiate new clinical or pre-clinical investigations to test therapeutic strategies, and some of these strategies could be successful and recognized as novel therapeutics for unmet medical needs.

1 November 2015 in Biomaterials
Verified
Journal Article
Closed access
Haitham Ali Badr El-Morsi BadrHaitham Ali Badr El-Morsi Badr
Haitham Ali Badr El-Morsi Badr
DADina AlSadek
Dina AlSadek
MMMohit P. Mathew
Mohit P. Mathew
CLChen-Zhong Li
Chen-Zhong Li
Leyla Bulatovna DjansugurovaLeyla Bulatovna Djansugurova
Leyla Bulatovna Djansugurova
HAhafiz Ahmed
hafiz Ahmed

1 February 2017 in Biomaterials
Verified
Journal Article
Closed access
Haitham Ali Badr El-Morsi BadrHaitham Ali Badr El-Morsi Badr
Haitham Ali Badr El-Morsi Badr
DADina AlSadek
Dina AlSadek
MEMotawa E. El-Houseini
Motawa E. El-Houseini
CSChristopher T. Saeui
Christopher T. Saeui
MMMohit P. Mathew
Mohit P. Mathew
HAhafiz Ahmed
hafiz Ahmed