We report on the selection process leading to the sixth version of the Mixed Integer Programming Library, MIPLIB 2017. Selected from an initial pool of 5721 instances, the new MIPLIB 2017 collection consists of 1065 instances. A subset of 240 instances was specially selected for benchmarking solver performance. For the first time, these sets were compiled using a data-driven selection process supported by the solution of a sequence of mixed integer optimization problems, which encode requirements on diversity and balancedness with respect to instance features and performance data.

We develop and present a novel minimum estimation error variance waveform design method. The method optimizes the spectral shape of a unimodular radar waveform such that the performance of a joint radar-communications system that shares spectrum is maximized. We also develop the novel spectral water-filling SIC data rate, which employs the continuous spectral water-filling algorithm to obtain the optimal communications power spectrum. We perform a numerical study to compare the performance of the new technique with the previously derived spectral mask shaping method. The global estimation rate and the data rate capture the radar and the communications performance respectively.

The binding of peptide fragments of antigens to class II MHC is a crucial step in initiating a helper T cell immune response. The identification of such peptide epitopes has potential applications in vaccine design and in better understanding autoimmune diseases and allergies. However, comprehensive experimental determination of peptide-MHC binding affinities is infeasible due to MHC diversity and the large number of possible peptide sequences. Computational methods trained on the limited experimental binding data can address this challenge. We present the MultiRTA method, an extension of our previous single-type RTA prediction method, which allows the prediction of peptide binding affinities for multiple MHC allotypes not used to train the model. Thus predictions can be made for many MHC allotypes for which experimental binding data is unavailable.