Robotic exoskeletons have emerged as promising motion-assistive technologies to meet the growing demand for structured, personalized cancer rehabilitation. This review critically examines their application in enhancing functional recovery, alleviating cancer-related fatigue, and improving quality of life among cancer patients and survivors. We first outline current evidence-based exercise strategies in cancer rehabilitation, followed by an analysis of how robotic exoskeletons complement and extend these approaches by restoring mobility, strengthening musculature, and supporting psychological well-being. Additionally, we assess how well they combine with multimodal interventions like nutritional, psychological, and digital therapeutics and their benefits. The convergence of artificial intelligence, wearable sensors, and telemedicine is also reshaping the landscape of remote, adaptive rehabilitation. Despite encouraging preliminary data, widespread clinical adoption remains limited due to challenges related to cost, exoskeleton system accessibility, safety, and long-term efficacy. We call for large-scale clinical trials, interdisciplinary collaboration, and policy reforms to promote equitable access to robotic-assisted rehabilitation. Collectively, this review offers a comprehensive perspective on the technical principles, therapeutic potential, and future directions of robotic exoskeletons as innovative tools in cancer recovery.

Objective: The aim of the study was to develop a prediction nomogram based on clinical factors to assess the risk of postoperative complications in children with congenital choledochal cyst.Methods: The clinical data from 131 children who underwent choledochal cyst resection and Roux-en-Y hepaticojejunostomy in our hospital between January 2016 and December 2022 were retrospectively analyzed. The general information, clinical symptoms, procedure, biochemical indicators, and imaging data were recorded. A prolonged hospital stay induced by postoperative complications or a follow-up over 6 months was assessed as the event outcome. A logistics regression analysis was performed to screen for risk factors with statistical significance in inducing postoperative complications. Then, with the dataset split into the training group and internal validation group, the nomogram for the prediction of postoperative complications was developed based on a computer algorithm. In addition, the receiver operating characteristic (ROC) curve and calibration curve were performed for nomogram verification.Results: Of 131 children, the multivariate logistics regression analysis suggested that age ≤2 years [odds ratio (OR) 0.93; 95% confidence interval (CI) 0.15–5.65; p = 0.938], Todani classification type 1 (OR 36.58; 95% CI 4.14–871.74; p = 0.005), cyst wall thickness >0.4 cm (OR 10.82; 95% CI 2.88–49.13; p &lt; 0.001), with chronic cholecystitis (OR 7.01; 95% CI 1.62–38.52; p = 0.014), and choledochal cyst diameter (OR 1.01; 95% CI 0.99–1.03; p = 0.370) were predictors associated with the postoperative complications of choledochal cysts. The data were randomly divided into the training group (n = 92) and internal validation group (n = 39) to build the prediction nomogram including the appeal factors. The accuracy and discrimination of the model were evaluated using a ROC curve and calibration curve. The results showed that the nomogram area under the ROC curve [area under the curve (AUC) = 0.894; 95% CI 0.822–0.966; p < 0.001], validation (AUC = 0.844; 95% CI 0.804–0.952; p < 0.001), and Brier = 0.120 (95% CI 0.077–0.163p; p < 0.001) were indicative of the good stability and calibration of the predictive nomogram.Conclusion: The prognosis of congenital choledochal cysts was associated with multiple aspects of clinical factors. Combined with the internal validation, the novel prediction nomogram was suitable for evaluating the individualized risk of postoperative complications of choledochal cysts. The prediction nomogram could provide a more accurate strategy of procedure and postoperative follow-up for children with choledochal cysts.

Objective: The purpose of this study is to compare the intraoperative and postoperative outcomes of a trans-umbilical single-site plus one robot-assisted surgery and a trans-umbilical single-site laparoscopic surgery in the treatment of choledochal cysts.Methods: We retrospectively analyzed clinical data from 49 children diagnosed with choledochal cysts who were admitted to our hospital between June 2020 and December 2023. Among these patients, 24 underwent a trans-umbilical single-site plus one Da Vinci robot-assisted surgery (the robot group) and 25 underwent a trans-umbilical single-site laparoscopic-assisted surgery (the laparoscopic group). We compared differences in intraoperative and postoperative outcomes between the two groups.Results: There was no significant difference between the two groups of patients in terms of gender, age, weight, clinical symptoms, maximum cyst diameter, type, postoperative complications, and facial expression, leg movement, activity, crying, and comfortability (FLACC) scoring (p > 0.05). Compared with the patients in the laparoscopic group, those in the robot group had less intraoperative bleeding [10 (8–12) vs. 15 (11.5–18) ml, p < 0.001] and required less postoperative drainage tube indwelling time [5 (4–6) vs. 7 (5.5–8) day, p < 0.001], less postoperative fasting time [4 (3–4) vs. 6 (5–7) days, p < 0.001], and less postoperative hospitalization time [6 (6–7) vs. 8 (6–10) days, p < 0.001], but they required more operative time [385.5 (317.0–413.3) vs. 346.0 (287.0–376.5) min, p = 0.050] and consumed more hospitalization expenses (79,323 ± 3,124 vs. 31,121 ± 2,918 yuan, p < 0.001).Conclusion: The results of this study showed a shorter hospitalization time, quicker postoperative recovery, and less tissue damage but a higher cost and a longer operation time in patients who chose robotic surgery rather than laparoscopic surgery. With the continuous expansion of the scale of installed robot-assisted surgical systems and the gradual accumulation of the technical experience of surgeons, robot-assisted surgery may slowly surpass, and shows a trend to replace, laparoscopy because of its advantages.

A flap-endonuclease 1 (FEN1)-assisted loop-mediated isothermal amplification (LAMP) method was developed to identify three leading pathogens for CAP, namely, Streptococcus pneumoniae, Mycoplasma pneumoniae and Haemophilus influenzae.

Hirschsprung‑associated enterocolitis (HAEC) represents a severe complication of Hirschsprung disease, characterized by intestinal barrier dysfunction and life‑threatening inflammation. The present study systematically reviews the updated molecular mechanisms underlying HAEC pathogenesis, with particular focus on the tight junction (TJ) proteins claudin, occludin and zonula occludens protein 1 (ZO‑1) and their interactions with the actin cytoskeleton. The present review demonstrates that dysregulation of claudin family members, particularly upregulation of pore‑forming claudin‑2 and downregulation of barrier‑forming claudin‑4, disrupts intestinal homeostasis. Occludin undergoes cytokine‑mediated endocytosis through myosin light chain kinase (MLCK)/NF‑κB signaling, while ZO‑1 dysfunction impairs mechanical coupling between TJs and actin filaments. Furthermore, the present review identifies that inflammatory mediators, such as IL‑1β, TNF‑α and IFN‑γ, trigger actin cytoskeleton remodeling via the cofilin phosphorylation cycle and the Rho‑associated protein kinase/MLCK pathway, establishing a cycle of barrier breakdown. Importantly, the present review highlights the lipocalin 10/slingshot homologue 1/cofilin axis and TJ‑cytoskeleton interactions as mechanistic targets for future intervention in HAEC treatment. These findings provide a comprehensive mechanistic framework for understanding HAEC pathogenesis and offer novel targets for clinical intervention.