Narvadeshwar Kushwaha

Dr. Narvadeshwar Kushwaha

Pharmacy, Wayne State University, Detroit, Michigan, USA
orcid

Research Focus & Metrics

Academic Career Length

10Years (2017-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 September 2018 in Bioorganic Chemistry
Verified
Journal Article
Closed access
SCSrinivasulu Cherukupalli
Srinivasulu Cherukupalli
BCBalakumar Chandrasekaran
Balakumar Chandrasekaran
VKVladimir Krystof
Vladimir Krystof
RARajeshwar Reddy Aleti
Rajeshwar Reddy Aleti
NSNisar Sayyad
Nisar Sayyad
RKRajshekhar Karpoormath
Rajshekhar Karpoormath

1 May 2021 in European Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
FKFrancis Kayamba
Francis Kayamba
TMTeboho Malimabe
Teboho Malimabe
IAIdowu Kehinde Ademola
Idowu Kehinde Ademola
OPOfentse Jacob Pooe
Ofentse Jacob Pooe
Narvadeshwar KushwahaNarvadeshwar Kushwaha
Narvadeshwar Kushwaha
RKRajshekhar Karpoormath
Rajshekhar Karpoormath

1 November 2021 in Bioorganic & Medicinal Chemistry
Verified
Journal Article
Closed access
FKFrancis Kayamba
Francis Kayamba
MFMbuso Faya
Mbuso Faya
OPOfentse Jacob Pooe
Ofentse Jacob Pooe
BKBabita Kushwaha
Babita Kushwaha
Narvadeshwar KushwahaNarvadeshwar Kushwaha
Narvadeshwar Kushwaha
RKRajshekhar Karpoormath
Rajshekhar Karpoormath

1 October 2021 in Journal of Molecular Structure
Verified
Journal Article
Closed access
VOVincent A. Obakachi
Vincent A. Obakachi
Narvadeshwar KushwahaNarvadeshwar Kushwaha
Narvadeshwar Kushwaha
BKBabita Kushwaha
Babita Kushwaha
MMMavela Cleopus Mahlalela
Mavela Cleopus Mahlalela
SSSuraj Raosaheb Shinde
Suraj Raosaheb Shinde
RKRajshekhar Karpoormath
Rajshekhar Karpoormath

25 August 2021 in Journal of Sulfur Chemistry
Verified
Journal Article
Closed access
VOVincent A. Obakachi
Vincent A. Obakachi
BKBabita Kushwaha
Babita Kushwaha
Narvadeshwar KushwahaNarvadeshwar Kushwaha
Narvadeshwar Kushwaha
SMSithabile Mokoena
Sithabile Mokoena
AGAb Majeed Ganai
Ab Majeed Ganai
RKRajshekhar Karpoormath
Rajshekhar Karpoormath
Despite significant advances in understanding cancer pathogenesis, it continues to be one of the leading causes of death. Thus, there is an urgent need for the development of novel, more effective anticancer therapeutics. In recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new anticancer agents. An example is the 1,3,4-thiadiazole, a versatile scaffold widely studied in medicinal chemistry. The mesoionic character of the ring allows 1,3,4-thiadiazole-containing derivatives to cross the cellular membrane and interact strongly with biological targets leading to the possibility of low toxicity and high selectivity. This review attempts to collect the recent updates of synthetic methodology, structural activity relationship (SAR), and anticancer properties of 1,3,4-thiadiazole embedded derivatives, which can be considered potential anticancer agents. GRAPHICAL ABSTRACT

10 August 2023 in European Journal of Medicinal Chemistry
Verified
Journal Article
Open access
Narvadeshwar KushwahaNarvadeshwar Kushwaha
Narvadeshwar Kushwaha
Jivanka MohanJivanka Mohan
Jivanka Mohan
BKBabita Kushwaha
Babita Kushwaha
TGTerisha Ghazi
Terisha Ghazi
JNJoshua C. Nwabuife
Joshua C. Nwabuife
ACAnil Chuturgoon
Anil Chuturgoon
The recently discovered coronavirus, known as SARS-CoV-2, is a highly contagious and potentially lethal viral infection that was declared a pandemic by the World Health Organization on March 11, 2020. Since the beginning of the pandemic, an unprecedented number of COVID-19 vaccine candidates have been investigated for their potential to manage the pandemic. Herein, we reviewed vaccine development and the associated research effort, both traditional and forward-looking, to demonstrate the advantages and disadvantages of their technology, in addition to their efficacy limitations against mutant SARS-CoV-2. Moreover, we report repurposed drug discovery, which mainly focuses on virus-based and host-based targets, as well as their inhibitors. SARS-CoV-2 targets include the main protease (Mpro), and RNA-dependent RNA-polymerase (RdRp), which are the most well-studied and conserved across coronaviruses, enabling the development of broad-spectrum inhibitors of these enzymes.