Jinxi Wang

Dr. Jinxi Wang


Research Focus & Metrics

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 March 2017 in Journal of Orthopaedics
Verified
Journal Article
Closed access
MBMitchell C. Birt
Mitchell C. Birt
DADavid W. Anderson
David W. Anderson
ETE. Bruce Toby
E. Bruce Toby
JWJinxi Wang
Jinxi Wang

1 September 2016 in Genes & Diseases
Verified
Journal Article
Open access
YFYi Feng
Yi Feng
BEBrian Egan
Brian Egan
JWJinxi Wang
Jinxi Wang
Low back pain (LBP) is a major cause of disability and imposes huge economic burdens on human society worldwide. Among many factors responsible for LBP, intervertebral disc degeneration (IDD) is the most common disorder and is a target for intervention. The etiology of IDD is complex and its mechanism is still not completely understood. Many factors such as aging, spine deformities and diseases, spine injuries, and genetic factors are involved in the pathogenesis of IDD. In this review, we will focus on the recent advances in studies on the most promising and extensively examined genetic factors associated with IDD in humans. A number of genetic defects have been correlated with structural and functional changes within the intervertebral disc (IVD), which may compromise the disc's mechanical properties and metabolic activities. These genetic and proteomic studies have begun to shed light on the molecular basis of IDD, suggesting that genetic factors are important contributors to the onset and progression of IDD. By continuing to improve our understanding of the molecular mechanisms of IDD, specific early diagnosis and more effective treatments for this disabling disease will be possible in the future.

1 March 2015 in Osteoarthritis and Cartilage
Verified
Journal Article
Closed access
KCK.L. Caldwell
K.L. Caldwell
JWJinxi Wang
Jinxi Wang

19 September 2020 in European Spine Journal
Verified
Journal Article
Closed access
PDF file
BMBin Meng
Bin Meng
JBJoshua Bunch
Joshua Bunch
DBDouglas Burton
Douglas Burton
JWJinxi Wang
Jinxi Wang

1 January 2015 in Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
Verified
Journal Article
Open access
DBDarryl Blalock
Darryl Blalock
AMAndrew Miller
Andrew Miller
MTMichael Tilley
Michael Tilley
JWJinxi Wang
Jinxi Wang
Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA.

1 February 2014 in Critical Reviews in Oncology/Hematology
Verified
Journal Article
Closed access
TKThomas E. Kruger
Thomas E. Kruger
AMAndrew H. Miller
Andrew H. Miller
AGAndrew K. Godwin
Andrew K. Godwin
JWJinxi Wang
Jinxi Wang