Background/Aims: This study aimed to investigate the possible positive effects of arbutin in a trinitrobenzene sulfonic acid (TNBS)- induced experimental colitis model, to compare it with mesalazine, which is used in treating inflammatory bowel disease and to observe the effect of its concomitant use. Materials and Methods: Forty Wistar albino species male rats were randomized into 5 groups as control, colitis, colitis+arbutin (Arb), colitis+mesalazine (Mes), and colitis+mesalazine+arbutin (M+A). Proinflammatory cytokines [interleukin (IL)-6, IL-1β, tumor necrosis factor alpha (TNF-α)] and oxidant/antioxidant parameters [malondialdehyde (MDA), superoxide dismutase inhibition (SOD) inhibition, myeloperoxidase (MPO), and catalase, glutathione peroxidase (GPx)] were processed from the samples. Histopathological evaluation evaluated goblet cell reduction, cellular infiltration, and mucosal loss. Results: When the treatment groups and the TNBS group were compared, statistical significance was achieved in MDA, MPO, SOD inhibition, GPx values, IL-6, IL-1β and TNF-α levels. Histopathological evaluation revealed a statistically significant decrease in the mucosal loss value in the group where mesalazine and arbutin were used together compared to the TNBS group. Conclusion: Our study’s results elaborated that using arbutin alone or in combination with mesalazine produced positive effects in colitis-induced rats. Cite this article as: Alemdar MB, Şirinyıldız F, Coşkun A, et al. Investigation of possible positive effects of arbutin application in experimental colitis model. Turk J Gastroenterol. 2024;35(7):523-531.

Aims: Endoscopic submucosal dissection (ESD) is an established technique for the curative resection of large colorectal lesions; however, intraoperative bleeding remains a major technical challenge. Electrosurgical coagulation modes are modifiable procedural factors that may influence bleeding control and procedural efficiency. This study aimed to compare the clinical outcomes of Swift and Spray coagulation modes during colorectal ESD. Methods: This retrospective, single-center study included 594 consecutive patients who underwent colorectal ESD between January 2021 and December 2025. Patients were divided into the Spray and Swift coagulation groups according to the coagulation mode used during submucosal dissection. Procedural characteristics, intraoperative and delayed bleeding, perforation rates, and other adverse events were analyzed and compared between groups. Results: Baseline patient and lesion characteristics were comparable between the two groups. The mean procedure time was significantly shorter in the Spray coagulation group compared with the Swift coagulation group (42.2±23.7 vs 51.7±31.9 minutes, p

Objective: In this study we aimed to compare the clinical and biochemical characteristics of primary Sjögren’s syndrome patients with that of keratoconjunctivitis sicca, secondary Sjögren syndrome and undifferentiated disease. Patients and Methods: Patients with Sjögren’s syndrome and keratoconjunctivitis sicca who applied between August 2009 and January 2010 were included in this study. Demographic data, laboratory characteristics, Schirmer’s test and salivary gland biopsies of the patients were recorded. Results: Average diagnosis age for 87 primary Sjögren’s syndrome, 25 secondary Sjögren’s syndrome, 27 keratoconjunctivitis sicca and 44 undifferentiated group patients were 45±13, 43±14, 44±11 ve 45±11 years (p>0.05), accordingly. Critical and severe mouth dryness rate was 45% in primary Sjögren’s syndrome group and 7% in keratoconjunctivitis sicca group, critical and severe eye dryness was 43% in primary Sjögren’s syndrome group and 78% in keratoconjunctivitis sicca group (p<0.001). Grade 3≥ positivity in salivary gland biopsy was found as 71.2% in primary Sjögren’s syndrome group and 27.2% in the undifferentiated group (p<0.001). Conclusions: More dense lymphocyte infiltration was detected in primary Sjögren’s syndrome in salivary gland biopsies. As 27.2% of undifferentiated group patients had positive salivary gland biopsies, they might need follow-ups in terms of having increased risk of developing primary Sjögren’s syndrome.

Objective: Helicobacter pylori (Hp) infection is one of the most common infections in the world. There are studies showing that the prevalence of Hp has decreased over the years. In this study, while trying to determine the prevalence of patients diagnosed with Hp histopathologically in our region and the change in this prevalence over the years, it was also tried to determine the relationship between endoscopic diagnosis and Hp and the change in this relationship over the years. Methods: Patients who underwent esophagogastroduodenoscopy at the Adnan Menderes University Gastroenterology Endoscopy Unit between 1998 and 2000 and 2018 and 2020 were included in the study. Helicobacter pylori status and endoscopic diagnoses were recorded in the patients. Helicobacter pylori was detected histopathologically. Results: A total of 6622 patients, 3791 between 1998 and 2000 and 2831 between 2018 and 2020, were included in the study. Heliobacter pylori positivity rate was 49.5% between 1998 and 2000, and 27.3% between 2018 and 2020 (P .0001). While Hp positivity rate was 78.1% in bulber ulcer, 54.4% in gastric ulcer, and 34.3% in gastric cancer between 1998 and 2000, this rate was found to be 32.3% in bulber ulcer, 38.1% in gastric ulcer, and 8.3% in gastric cancer between 2018 and 2020. (P=.0001, P=.004, P=.012). Conclusion: In this study, we found that the prevalence of Hp decreased from 49.5% to 27.3% in 20 years in our region. This decrease was observed in all endoscopic diagnoses, and the decreases were statistically significant. In the decrease of Hp prevalence, in addition to eradication treatment, we think that factors such as improved sanitation conditions and increased education/socioeconomic level also play a role.