To investigate the impact of high circulating AMH on the outcome of CC ovulation induction in women with PCOS. This prospective cohort observational study included 81 anovulatory women with PCOS who underwent 213 cycles of CC ovarian stimulation. Serum AMH concentrations were measured on cycle day 3 before the commencement of CC in the first cycle, which were compared between responders and CC-resistant anovulation (CRA). Logistic regression analysis was applied to study the value of serum AMH for the prediction of ovarian responsiveness to CC stimulation. The receiver-operating characteristic (ROC) curve was used to evaluate the prognostic value of circulating AMH. Serum AMH levels. Women who ovulated after CC therapy had a significantly lower AMH compared with the CRA (5.34 ± 1.97 vs.7.81 ± 3.49, P < 0.001). There was a significant gradient increase of serum AMH levels with the increasing dose of CC required to achieve ovulation (P < 0.05). In multivariate logistic regression analysis, AMH was an independent predictor of ovulation induction by CC in PCOS patients. ROC curve analysis showed AMH to be a useful predictor of ovulation induction by CC in PCOS patients, having 92 % specificity and 65 % sensitivity when the threshold AMH concentration was 7.77 ng/ml. Serum AMH may be clinically useful to predict which PCOS women are more likely to respond to CC treatment and thus to direct the selection of protocols of ovulation induction.

Vulvar lichen sclerosus (VLS) is a chronic, progressive dermatological condition characterized by recurrent episodes that often lead to persistent vulvar itching, pain, burning sensations, and in some cases, atrophy and scarring of the vulvar skin. These symptoms severely impact the patient's quality of life. Various treatments are used in clinical practice both domestically and internationally; however, due to the unknown etiology, prolonged disease course, difficulty in achieving a cure, and high recurrence rates, there is still a lack of effective therapies. The combined use of Traditional Chinese and Western medicine has shown certain advantages in alleviating symptoms, improving the disease course, and enhancing patients' quality of life. This article reviews the progress in research on the combined treatment of vulvar lichen sclerosus with Traditional Chinese and Western medicine, discusses the advantages of this integrative approach, and aims to provide new perspectives and methods for the treatment of VLS.