Background: Hematopoietic stem cell transplantation (HSCT) is a potentially curative procedure that is used in various hematological malignancies. However, among an increasing number of HSCT, the amount of cancer therapy-related cardiac dysfunction (CTRCD) is increasing as well. This study aimed to determine the prevalence of subclinical CTRCD in HSCT patients 12 months after HSCT and to assess the impact of clinical factors on the development of CTRCD. Material and Methods: We included 55 patients who underwent autologous or allogeneic HSCT. The patients were assessed using an echocardiography method before and 12 months after a HSCT procedure. Results: Our study revealed that during the 12-month follow-up period, asymptomatic CTRCD was observed in 15 patients (27.3%), 6 experienced moderate CTRCD, and 9 experienced mild CTRCD. Patients with previous use of anthracyclines tended to have CTRCD more often: nine patients (60%) in the CTRCD group and nine patients (22.5%) in non-CTRCD group. Patients who received the BEAM regimen for conditioning also experienced CTRCD more often: five patients (33.3%) in CTRCD group vs. two patients (5%) in the non-CTRCD group. Conclusions: Our study showed that asymptomatic CTRCD was found in 27.3% of the patients 12 months after HSCT. The BEAM chemotherapy conditioning protocol following prior anthracycline use were identified as factors contributing to the development of CTRCD.

Background and Objectives: Heart failure (HF) is a complex clinical syndrome with a high prevalence and significant morbidity. Classification of HF into preserved (HFpEF), mildly reduced (HFmrEF), and reduced ejection fraction (HFrEF) groups helps improve patient stratification and treatment. This study aimed to compare clinical, laboratory, echocardiographic, and electrocardiographic characteristics between different HF ejection fraction groups in a single-center patient cohort. Materials and Methods: A retrospective analysis of 1144 patients hospitalized with HF between 2022 and 2023 was performed. Patients were divided into three groups based on left ventricular ejection fraction. Results: HFrEF patients were predominantly male and younger, while HFpEF and HFmrEF groups had a higher proportion of older females. Atrial fibrillation and arterial hypertension were more common in HFpEF, while HFrEF patients showed more significant ventricular and atrial remodeling, lower tricuspid annular plane systolic excursion (TAPSE) values, and higher N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. No significant difference in in-hospital outcomes was found between HF groups. Conclusions: HF subtypes demonstrate distinct clinical and structural profiles, supporting the need for phenotype-based diagnostic and therapeutic approaches.