This study investigates novel zinc and indium phthalocyanines with Schiff base and sulphur moieties, focusing on their potential for cancer therapy and antimicrobial applications.

In this study, we report the synthesis of thieno[2,3‐ c ]pyridine derivatives by a metal‐free method via fused 1,2,3‐triazoles. In the synthesis of this skeleton using a three‐step method, we first obtained 1‐(2,2‐dimethoxyethyl)‐5‐(thiophen‐2‐yl)‐1 H ‐1,2,3‐triazole through a one‐pot triazolation reaction and in the next step, we synthesized the thieno[2,3‐ c ][1,2,3]triazolo[1,5‐ ɑ ]pyridine compound using a modified Pomeranz‐Fritsch reaction. In the final step, the synthesis of thieno[2,3‐ c ]pyridine derivatives was achieved in good yield via acid‐mediated denitrogenative transformation reactions. This mild condition synthetic process has enabled access to the title compounds, of which limited examples have been reported until now in the literature. Thus, the syntheses of 7‐(substituted methyl)thieno[2,3‐ c ]pyridine, thieno[2,3‐ c ]pyridine‐7‐ylmethyl esters, and imidazo[1,5‐ ɑ ]thieno[2,3‐ c ]pyridine derivatives have been successfully achieved.

In this study, β-2-heteroaryl substituted (N-methyl 2-pyrrolyl, 2-thiophenyl, 2-furyl) α,β-unsaturated ketones were reacted with two α-diazo carbonyl compounds that had different characteristics (dimethyl diazo malonate and 1-diazo-1-phenyl-propane-2-one) in the presence of both copper and rhodium catalysts. In the case of reactions with N-methyl 2-pyrrolyl α,β-unsaturated ketones, the major product was the insertion derivative. However, in the reactions of 2-thiophenyl and 2-furyl α,β-unsaturated ketones with dimethyl diazomalonate (acceptor-acceptor disubstituted), only dihydrofuran products were formed over carbonyl ylides. When 2-thiophenyl and 2-furyl α,β-unsaturated ketones were reacted with 1-diazo-1-phenyl-propane-2-one (donor-acceptor disubstituted), 1-phenylpropane-1,2-dione was obtained under our reaction conditions.