Background: Disseminating disease knowledge through concise videos on various platforms is an innovative and efficient approach. However, it remains uncertain whether pancreatic neuroendocrine tumor (pNET)-related videos available on current short video platforms can effectively convey accurate and impactful information to the general public. Objective: Our study aims to extensively analyze the quality of pNET-related videos on TikTok and Bilibili, intending to enhance the development of pNET-related social media content to provide the general public with more comprehensive and suitable avenues for accessing pNET-related information. Methods: A total of 168 qualifying videos pertaining to pNETs were evaluated from the video-sharing platforms Bilibili and TikTok. Initially, the fundamental information conveyed in the videos was documented. Subsequently, we discerned the source and content type of each video. Following that, the Global Quality Scale (GQS) and modified DISCERN (mDISCERN) scale were employed to appraise the educational value and quality of each video. A comparative evaluation was conducted on the videos obtained from these two platforms. Results: The number of pNET-related videos saw a significant increase since 2020, with 9 videos in 2020, 19 videos in 2021, 29 videos in 2022, and 106 videos in 2023. There were no significant improvements in the mean GQS or mDISCERN scores from 2020 to 2023, which were 3.22 and 3.00 in 2020, 3.33 and 2.94 in 2021, 2.83 and 2.79 in 2022, and 2.78 and 2.94 in 2023, respectively. The average quality scores of the videos on Bilibili and Tiktok were comparable, with GQS and mDISCERN scores of 2.98 on Bilibili versus 2.77 on TikTok and 2.82 on Bilibili versus 3.05 on TikTok, respectively. The source and format of the videos remained independent factors affecting the two quality scores. Videos that were uploaded by professionals (hazard ratio=7.02, P=.002) and recorded in specialized popular science formats (hazard ratio=12.45, P<.001) tended to exhibit superior quality. Conclusions: This study demonstrates that the number of short videos on pNETs has increased in recent years, but video quality has not improved significantly. This comprehensive analysis shows that the source and format of videos are independent factors affecting video quality, which provides potential measures for improving the quality of short videos.

The incidence of non-alcoholic fatty liver (NAFLD) remains high, and many NAFLD patients suffer from severe ischemia-reperfusion injury (IRI). Currently, no practical approach can be used to treat IRI. Puerarin plays a vital role in treating multiple diseases, such as NAFLD, stroke, diabetes, and high blood pressure. However, its role in the IRI of the fatty liver is still unclear. We aimed to explore whether puerarin could protect the fatty liver from IRI. C57BL/6J mice were fed with a high‐fat diet (HFD) followed by ischemia reperfusion injury. We showed that hepatic IRI was more severe in the fatty liver compared with the normal liver, and puerarin could significantly protect the fatty liver against IRI and alleviate oxidative stress. The PI3K-AKT signaling pathway was activated during IRI, while liver steatosis decreased the level of activation. Puerarin significantly protected the fatty liver from IRI by reactivating the PI3K-AKT signaling pathway. However, LY294002, a PI3K-AKT inhibitor, attenuated the protective effect of puerarin. In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway.

Background: Transarterial chemoembolization (TACE) is a widely used treatment for advanced, unresectable hepatocellular carcinoma, often requiring multiple sessions for optimal efficacy. TikTok and Bilibili have gained widespread popularity as easily accessible sources of health information. Objective: This study aims to assess the quality of the information in Chinese short videos on TACE shared on TikTok and Bilibili. Methods: In November 2024, the top 100 TACE-related Chinese-language short videos on TikTok and Bilibili (a total of 200 videos) were assessed and reviewed. Initially, basic information about the videos was recorded and analyzed. Subsequently, Global Quality Score and the DISCERN tool were used to evaluate the information quality and reliability of the videos on both platforms. Finally, multifactorial analysis was used to identify potential factors influencing the quality of the videos. Results: TikTok is more popular than Bilibili, despite its videos being shorter in length (P<.001). The quality of short videos on TACE found on both platforms was of low quality, with average Global Quality Score scores of 2.31 (SD 0.81) on TikTok and 2.48 (SD 0.80) on Bilibili, as well as DISCERN scores of 1.86 (SD 0.40) on TikTok and 2.00 (SD 0.44) on Bilibili. The number of saves (β=.184, P=.008; β=.176, P=.01) and days (β=.214, P=.002; β=.168, P=.01) since publication were identified as closely related variables to video quality and reliability. Furthermore, the duration of the video was closely related to its reliability (β=.213, P=.002). Conclusions: This study indicates that the quality of TACE-related health information in the top 100 short videos on both Bilibili and TikTok platforms is suboptimal. Patients should exercise caution when relying on health-related information from these platforms. Social media companies should establish review teams with basic medical knowledge. It is essential for the platforms to enhance their recommendation algorithms and implement measures for video quality assessment. Health care professionals should be aware of the limitations of these videos and work to improve their quality.

Liver cancer has long ranked among the leading causes of cancer-related deaths in China. Although hepatitis B virus (HBV) and hepatitis C virus (HCV) were