Spontaneous resorption of lumbar disk herniation (LDH) presents a promising avenue for the non-surgical management of herniated disks. Here we present a 40-year-old female with severe L5/S1 herniation who experienced spontaneous resorption confirmed by MRI. The patient adhered to a comprehensive non-operative treatment regimen comprising NSAIDs, heat therapy, massage therapy, acupuncture, and kinesitherapy. Over two years, the patient showed substantial clinical improvement, with significant pain reduction and MRI evidence of disk resorption, resulting in a marked decrease in their visual analog scale (VAS) pain scores. Through a systematic review of existing literature, we identify that spontaneous resorption is associated with mechanisms such as inflammation, neovascularization, macrophage infiltration, matrix degradation, disruption of immune privilege, apoptosis and autophagy, and disc dehydration. Clinical predictors for spontaneous resorption of LDH include the size, type and composition of the herniation, rim enhancement on contrast-enhanced MRI, and involvement of the posterior longitudinal ligament (PLL). Future research should focus on elucidating the molecular mechanisms of resorption, regulation of inflammatory response, macrophage polarization, matrix degradation, immune privilege and neovascularization, developing advanced imaging techniques to predict resorption potential, and exploring personalized treatment strategies based on machine learning and deep learning prediction models.

To analyze the research status and development prospects of hydrogels in the field of bone regeneration based on bibliometric methods. In the Web of Science Core Collection database, a total of 1382 representative articles related to the application of hydrogels in bone regeneration were selected as of the end of 2023. Utilizing the tools VOSviewer and CiteSpace, an in-depth bibliometric visualization analysis was conducted to reveal the countries, authors, core literature, and journals that are highly productive in this field. Additionally, the research trends and development prospects within this area were analyzed. This study uses VOSviewer and CiteSpace to analyze 1382 highly cited articles on bone regeneration and materials science, revealing key trends and the evolution of the field. The United States, China, South Korea, Germany, the UK, and Japan are the leading countries in scientific output, with strong collaboration networks. Major research institutions, particularly in China and Japan, focus on hydrogels for bone regeneration. Top journals include International Journal of Biological Macromolecules and Acta Biomaterialia. Key authors include Timothy E. L. Douglas, known for developing mineralization-enhanced hydrogels, and Robert E. Guldberg, focused on growth factor delivery systems. The field has shifted from simple filling materials to multifunctional composites, with advancements in gene editing, signaling molecules, and bone regeneration drugs. Future trends include smart hydrogels, 3D printing, bioactive factor integration, cell engineering, and optimizing biodegradability and biocompatibility. Multifunctional composite hydrogels are expected to become the go-to materials for clinical bone repair. Advancements in technology have transformed hydrogels from simple fillers to multifunctional composites, playing a crucial role in bone regeneration. Future trends include smart hydrogels, 3D printing, bioactive factor integration, cell engineering, and optimized biodegradability and biocompatibility. These developments indicate hydrogels will become the preferred material for clinical bone defect repair, significantly enhancing bone tissue repair and regeneration.

Re-rupture following anterior cruciate ligament (ACL) reconstruction remains a challenging complication, necessitating effective revision strategies. To evaluate the clinical and technical outcomes of synthetic ligament-based revision ACL reconstruction for postoperative re-rupture, a retrospective analysis was conducted on patients undergoing synthetic ligament revision ACL reconstruction between January 2023 and January 2024. Preoperative assessments included laboratory tests (ESR, CRP, tuberculosis antibodies), radiographic imaging (X-ray, CT, MRI), and functional scoring (VAS, IKDC, Lysholm). Surgical protocols emphasized meticulous tunnel planning, arthroscopic debridement, synthetic ligament placement, and dual fixation with metallic interference screws. Postoperative care involved early mobilization, systematic rehabilitation, and regular follow-ups. Results showed that the procedure demonstrated technical feasibility, with successful ligament fixation and no intraoperative complications. Postoperative evaluations revealed improved functional scores (IKDC, Lysholm) and reduced pain (VAS). Imaging confirmed proper ligament positioning and graft integrity. No instances of infection, graft failure, or significant joint instability were reported during follow-up. Those results indicate that synthetic ligament revision ACL reconstruction offers a reliable solution for re-rupture cases, combining precise surgical techniques with rigorous postoperative rehabilitation. This approach addresses anatomical challenges, restores knee stability, and enhances patient outcomes, supporting its adoption in complex revision scenarios.

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Re-rupture following anterior cruciate ligament (ACL) reconstruction remains a challenging complication, necessitating effective revision strategies. To evaluate the clinical and technical outcomes of synthetic ligament-based revision ACL reconstruction for postoperative re-rupture, a retrospective analysis was conducted on patients undergoing synthetic ligament revision ACL reconstruction between January 2023 and January 2024. Preoperative assessments included laboratory tests (ESR, CRP, tuberculosis antibodies), radiographic imaging (X-ray, CT, MRI), and functional scoring (VAS, IKDC, Lysholm). Surgical protocols emphasized meticulous tunnel planning, arthroscopic debridement, synthetic ligament placement, and dual fixation with metallic interference screws. Postoperative care involved early mobilization, systematic rehabilitation, and regular follow-ups. Results showed that the procedure demonstrated technical feasibility, with successful ligament fixation and no intraoperative complications. Postoperative evaluations revealed improved functional scores (IKDC, Lysholm) and reduced pain (VAS). Imaging confirmed proper ligament positioning and graft integrity. No instances of infection, graft failure, or significant joint instability were reported during follow-up. Those results indicate that synthetic ligament revision ACL reconstruction offers a reliable solution for re-rupture cases, combining precise surgical techniques with rigorous postoperative rehabilitation. This approach addresses anatomical challenges, restores knee stability, and enhances patient outcomes, supporting its adoption in complex revision scenarios.

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