In the era of the digital economy (DE), technology factors and data factors, like a two-wheel drive, have not only redefined the mode of production but also innovatively reshaped production relations. To examine how the DE can ensure food security (FS) in China, this study explores the negative impacts of land resource mismatch (LRM) on FS, the mechanisms of the impacts, and the critical role played by the DE in mitigating its negative impacts, based on China’s provincial-level panel data from 2011 to 2022. This study finds that, first, LRM leads to a reduction in food production, which, in turn, threatens FS, and this conclusion remains robust after a series of robustness tests. Second, the heterogeneity analysis finds that LRM has a greater negative impact on FS in regions with high urbanization levels, regions with a short tenure of officials, and regions that are not major food-producing regions. Finally, in a further analysis, the specific channels and solution paths of the negative impact of LRM on FS are explored in depth. LRM negatively affects the material base and production capacity of food production, including reducing the supply of land, labor, and capital factors for food production; the DE reduces the negative impact of LRM on FS through the use of digital technology and open government data.