Supraorbital hollowness and pretarsal fullness, commonly known as the sunken eyelid and charming roll, respectively, are significant anatomical features that impact the aesthetic appearance of the periorbital region. Supraorbital hollowness is characterized by a recessed appearance of the upper eyelid, often attributed to genetic factors, aging, or surgical alterations, such as excessive fat removal during blepharoplasty. This condition is particularly prevalent among East Asians due to anatomical differences, such as weaker levator muscles and unique fat distribution patterns. Pretarsal fullness, also known as aegyo-sal, enhances the youthful and expressive appearance of the lower eyelid, forming a roll above the lash line that is considered aesthetically desirable in East Asian culture. Anatomical-based filler injection techniques are critical for correcting these features, involving precise placement within the correct tissue planes to avoid complications and achieve natural-looking results. This approach not only improves the aesthetic appeal of the eyelid but also enhances the overall facial harmony, emphasizing the importance of tailored procedures based on individual anatomy and cultural preferences.

Chronic lower-extremity ulcers remain difficult to treat, particularly in patients with metabolic and vascular comorbidities. This multicentre case series describes four patients with chronic lower-extremity ulcers that persisted for at least 6 months despite conventional management. The study evaluated topical application of edelweiss callus culture extract–derived exosomes (P198 Exo-HL FILCORE SB PLUS, Primoris International Co., Ltd., Seoul, Korea) used as an adjunct to standard wound care. All ulcers had persisted for at least 6 months despite conventional management. After wound cleansing and debridement as required, exosomes (0.5–1.0 mL; approximately 0.1 mL/cm²) were applied directly to the wound bed at monthly visits, followed by non-adherent sterile dressings. Clinical progress was documented by serial photography and wound measurements. Arterial and venous Doppler ultrasonography was performed at baseline and at 3-month intervals to assess changes in perfusion and venous reflux. Across the series, all patients demonstrated progressive granulation and re-epithelialisation without treatment-related adverse events. Early size reduction was observed within 15 days in one case, complete granulation and re-epithelialisation occurred within 60 days in another, and near-complete closure was achieved over 5–7 months in a third. In a severe post-infective ulcer for which amputation had been recommended, complete closure was achieved over approximately 6 months. Doppler parameters improved in all cases, including reductions in resistive index and venous reflux time and/or increases in peak systolic velocity. This small, uncontrolled series suggests that topical exosome therapy may be a feasible adjunct in refractory chronic ulcers, with concurrent improvements in clinical healing and Doppler-assessed vascular dynamics. Larger controlled studies are required to define efficacy and optimal treatment schedules.