Drawing on the social capital theory, the research examines the impact of network size, network centrality, trust, and regulation on the knowledge integration and robustness of emergency medical logistics. Additionally, the research seeks to provide deeper insight into the link between the variables by studying how knowledge integration mediates the relationship between independent variables and the robustness of emergency medical logistics. The study utilized structural equation modeling to assess the underlying assumptions of the research model. A total of 465 valid questionnaires were collected from government departments, hospitals, social teams, and enterprises. The data processing and analysis were conducted using SPSS 23.0 and AMOS 24.0 software. The study’s outcome indicated that network size and network centrality have indirect effects on the robustness of emergency medical logistics through the intermediate variable of knowledge integration, but neither has a direct effect. Moreover, knowledge integration has a significant positive impact on the robustness of emergency medical logistics. Both trust and regulation have positive effects on the robustness of emergency medical logistics, and they also have positive effects on the robustness of emergency medical logistics through knowledge integration. This study is the inaugural exploration of the correlation between knowledge integration and the robustness of emergency medical logistics. It adds to the literature by providing evidence that knowledge integration is an essential emergency organization’s aide in promoting the robustness of emergency medical logistics. The findings of this study establish a strong theoretical foundation and practical significance for ensuring and improving the level of effectiveness in emergency medical logistics management.