Introduction: Multiple myeloma (MM) is highly associated with cardiovascular complications, and their co-existence significantly increases the risk of cardiovascular events and mortality, predominantly in older adults. Therefore, we aim to analyze MM and cardiovascular disease (CVD) mortality trends in older adults from 1999 to 2023 in the United States (U.S). Methods: A retrospective analysis of Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database was conducted from 1999 to 2023, including death records of adults (aged 65 ≤) with MM and CVDs. Age-adjusted mortality rates (AAMR) per 100,000 population and annual percent changes (APC) in AAMRs were calculated and measured across different demographics and geographies in the U.S. Results: MM and CVD have caused a total of 99,637 deaths. AAMR increased from 9.6 in 1999 to 9.9 in 2023, with a prominent surge noted between 2018 and 2021 (APC: 6.82). Males (12.5) had almost double the AAMR that of females (7.0), while the AAMR of 18.6 was seen in NH African Americans, triple that of other races/ethnicities. Geographically, AAMR was higher in metropolitan areas (9.2) and the Northeast region (10.1). Conclusions: Proper resource distribution and more targeted interventions are needed to address the rising trends in MM and CVD-associated mortality across different geographic and demographic groups.

Diabetes mellitus (DM) and liver cirrhosis are highly co-occurring conditions contributing significantly to global mortality over the past two decades. We aimed to examine nationwide mortality patterns for DM and liver cirrhosis from 1999 to 2023. Trends in DM and liver cirrhosis mortality were analyzed using death certificates from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. Crude and age-adjusted mortality rates (AAMRs) per 100,000 people and annual percent changes (APCs) in AAMR were obtained with their 95% confidence intervals (CIs) and measured across different demographic and geographic subgroups. Overall, 112,644 deaths were attributed to DM and liver cirrhosis among adults aged ≥45. The total AAMR increased twofold from 1999 (2.8) to 2023 (5.2) while peaking in 2021 (13.71, P < 0.05), followed by a post-COVID decline by 2023. Demographic groups with the highest AAMRs included males (4.2), non-Hispanic American Indians (7.7), those in nonmetropolitan areas (3.8), and those in the West region (3.9). The rising mortality rates across different demographic characteristics and regions highlight the need for targeted interventions and resource distribution among high-risk populations, such as males and nonmetropolitan residents, to address these persistent disparities.

The circumscribed choroidal hemangioma (CCH) is a benign congenital eye tumor whose etiology is not clear. A 41‐year‐old female patient came with a 2‐year history of slowly progressive deteriorating vision in her right eye. In the left eye, the best‐corrected visual acuity (BCVA) was 6/6, and counting fingers at 1 m in the right eye. The wide‐field fundus showed a yellow macular lesion with indistinct limits, which is a sign of serous retinal detachment. B‐scan ultrasonography revealed a clear‐cut choroidal lesion, high internal reflectivity, and visible intrinsic vascularity on color Doppler. OCT has shown a massive choroidal mass with damaged RPE and outer retinal layers, which has been obscured by serous retinal detachment. The chest x‐ray revealed bronchiectatic opacities, the CT scan revealed no lung lesions, and LFTs and RFTs were normal. The fluorescein angiography revealed a choroidal hemangioma with early vascularity and late hyperfluorescence. Nonetheless, the retinal team chose the option of observation instead of TTT, radiotherapy, or verteporfin photodynamic therapy due to the closeness of the lesion to the macula, low visual acuity, and lack of verteporfin PDT in Pakistan. To sum up, the present case demonstrates the significance of multimodal imaging in the proper diagnosis of choroidal hemangiomas and the necessity to pay close attention to patient‐specific factors when making treatment decisions, especially in limited resource settings.