The International One Health Conference 2023, scheduled for October in Barcelona, fosters a collaborative, multidisciplinary approach to health involving professionals, academics, and decision-makers. Operating in a hybrid format, the conference aims to bridge the gap between scientific knowledge and policies, aligning with the Sustainable Development Goals (SDGs) and Health in All Policies (HiAP). Emphasizing community involvement and the symbiotic relationship between basic needs, sustainable lifestyles, and empowerment, the conference envisions a comprehensive approach to sustainable development. D’Alisa introduces a framework incorporating participative democracy, recognizing the interconnectedness of economic, social, environmental, and participative democratic dimensions. Framing questions for the conference delve into critical aspects, addressing the integration of the One Health framework within health sectors, emphasizing interlinkages between health, climate change, and decision-making. The conference’s five-dimension framework tackles the complexity of One Health, addressing concerns, solutions, and opportunities in a holistic paradigm.

Prehabilitation (PRH) is a preoperative process aimed at optimizing patients' functional capacity to improve surgical outcomes and overall well-being. While its physical and cognitive benefits are increasingly documented, its emotional impact, particularly in neuro-oncology patients, remains less explored. This study assessed the psychological effects of a PRH program on 29 brain tumor patients. The primary outcome, emotional well-being, was measured using quality of life and emotional distress metrices. Secondary outcomes included perceived stress levels and control attitudes. Additionally, qualitative data from structured interviews provided further insights into the psychological effects of the intervention. The results indicated significant improvements in quality of life and reductions in emotional distress, particularly among women. While perceived stress levels remained stable, control attitudes showed an increase. Qualitative analysis further highlighted the positive changes in the control sense and identified additional factors, such as the importance of social support sources during the PRH process. Overall, these findings suggest that PRH interventions play a significant role in enhancing emotional well-being among neuro-oncological patients in the preoperative phase. These results underscore the importance of implementing comprehensive and personalized PRH approaches to optimize clinical status both before and after surgery, thereby promoting sustained psychological benefits in this population. This study is based on data collected at Institut Guttmann in Barcelona in the context of the Prehabilita project (ClinicalTrials.gov identifier: NCT05844605 ; registration date: 06/05/2023).

The International One Health Conference 2024 took place against the backdrop of the Mediterranean, a region emblematic of humanity’s most pressing interconnected challenges, including climate change, environmental degradation, and persistent maternal and child health disparities

Patients with brain tumors involving language-critical regions face surgical limitations when balancing resection with preservation of function. Non-invasive neuromodulation-induced prehabilitation (NIP) aims to guide preoperative neuroplastic reorganization, potentially facilitating larger resections while preserving function. We investigated whether NIP selectively modulates the targeted language network compared with control networks, and whether such modulation is behaviorally safe. We enrolled 26 patients (mean age = 55.9 ± 11.8 years) from the Prehabilita project (Clinical Trial: NCT05844605 ) with operable brain tumors affecting language or motor regions. Eleven received language-targeted NIP, combining transcranial magnetic stimulation and/or transcranial direct current stimulation with intensive language training. Fourteen patients with NIP targeting non-language networks, primarily motor networks, served controls. Assessments included task-based functional magnetic resonance imaging (tb-fMRI) and a neuropsychological battery assessing language and cognitive domains before and after prehabilitation. Results indicated a group-specific NIP effect on the language network. In the language-targeted group, tb-fMRI revealed reduced overlap between a region of interest centered on the stimulation target and fMRI-derived language activation maps, whereas no comparable changes were observed in controls. No significant modulation effects were detected in the motor network in either group. These findings indicate that NIP can selectively reorganize the language network, with modulation patterns differing in sensorimotor networks. Importantly, language network modulation occurred while preserving language and cognitive performance. These results support NIP targeting higher-order functions such as language as a safe preoperative strategy that may reduce functional constraints on surgery and enable larger and safer resections in patients with tumors involving language-critical regions.