Yu-Chang Chen

Dr. Yu-Chang Chen


Research Focus & Metrics

Academic Career Length

28Years (1999-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 June 2005 in Planta Medica
Verified
Journal Article
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ITIan-Lih Tsai
Ian-Lih Tsai
FLFan-Pin Lee
Fan-Pin Lee
CWChin-Chung Wu
Chin-Chung Wu
CDChang-Yih Duh
Chang-Yih Duh
TITsutomu Ishikawa
Tsutomu Ishikawa
ICIh-Sheng Chen
Ih-Sheng Chen
Three new cyclobutanoid amides with trans-trans-trans configurations, piperarborenine C, piperarborenine D and piperarborenine E, and a new furanoid lignan, (+)-arborone, together with twelve known compounds, were isolated from the stems of Piper arborescens. The structures of these new compounds were determined by means of spectral analyses. Piperarborenine C, (+)-diayangambin, piplartine, piperolactam B, piperolactam C, aristolactam BIII, goniothalactam, and methyl trans-3,4,5-trimethoxycinnamate possessed anti-platelet aggregation activity in vitro. Among them, piplartine showed the most potent anti-platelet aggregation activity induced by collagen and showed an IC50 value of 21.5 μM. Piperarborenines A - E, piperarborenine, aristololactam BIII and goniothalactam showed significant cytotoxic activity (IC50 values < 4 μg/mL) against P-388, HT-29 and A549 cell lines in vitro.

14 September 2012 in Journal of Agricultural and Food Chemistry
Verified
Journal Article
Closed access
HKHan-Peng Kuo
Han-Peng Kuo
TCTzu-Chao Chuang
Tzu-Chao Chuang
STShih-Chang Tsai
Shih-Chang Tsai
HTHsiu-Hsueh Tseng
Hsiu-Hsueh Tseng
SHShih-Chung Hsu
Shih-Chung Hsu
MKMing-Ching Kao
Ming-Ching Kao

1 October 2000 in Planta Medica
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Journal Article
Closed access
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ITIan-Lih Tsai
Ian-Lih Tsai
WLWei-Yu Lin
Wei-Yu Lin
CTChe-Ming Teng
Che-Ming Teng
TITsutomu Ishikawa
Tsutomu Ishikawa
SDShin-Lian Doong
Shin-Lian Doong
ICIh-Sheng Chen
Ih-Sheng Chen
Further study on the chloroform-soluble portion of the root bark of Zanthoxylum schinifolium led to the isolation of eight new coumarins: methylschinilenol (1), hydroxyepoxycollinin I (2), 8-methoxyanisocoumarin H (3), hydroxyschininallylol (4), hydroxyepoxycollinin II (5), schinitrienin (6), schininallylone (7), and isoschinilenol (8), along with twenty-six known compounds including fourteen coumarins, and nine alkaloids. The structural elucidation was determined by spectroscopic data. Among the isolates, terpenyl-coumarins and furoquinolines were the active constituents with antiplatelet aggregation in vitro and collinin (10) showed significant anti-HBC DNA replication activity.

1 August 2007 in Phytochemistry
Verified
Journal Article
Closed access
YCYu-Chang Chen
Yu-Chang Chen
CLChang-Hui Liao
Chang-Hui Liao
ICIh-Sheng Chen
Ih-Sheng Chen

27 February 2004 in Helvetica Chimica Acta
Verified
Journal Article
Closed access
PDF file
FLFan‐Pin Lee
Fan‐Pin Lee
YCYu-Chang Chen
Yu-Chang Chen
JCJih‐Jung Chen
Jih‐Jung Chen
ITIan‐Lih Tsai
Ian‐Lih Tsai
ICIh‐Sheng Chen
Ih‐Sheng Chen

31 December 2001 in Planta Medica
Verified
Journal Article
Closed access
PDF file
JCJih-Jung Chen
Jih-Jung Chen
YCYa-Ling Chang
Ya-Ling Chang
CTChe-Ming Teng
Che-Ming Teng
WLWei-Yu Lin
Wei-Yu Lin
YCYu-Chang Chen
Yu-Chang Chen
ICIh-Sheng Chen
Ih-Sheng Chen
A new tetrahydroprotoberberine N-oxide alkaloid, (-)-cis-isocorypalmine N-oxide (1), together with two known compounds, 6-methoxydihydrosanguinarine (2) and norjuziphine (3), were isolated in continuing studies of the entire Formosan Corydalis tashiroi plant. The structures of these three compounds were determined through spectral analyses. In addition, compounds 1, 2, 3 and the seven alkaloids previously reported: (-)-cis-corydalmine N-oxide, (-)-trans-corydalmine N-oxide, (-)-trans-isocorypalmine N-oxide, scoulerine, protopine, oxysanguinarine and corydalmine, were found to possess anti-platelet aggregation activity.