Актуальность: Распространенность ожирения с каждым годом растет среди населения, в том числе среди женщин детородного возраста. Более трети женщин репродуктивного возраста имеют избыточный вес или страдают ожирением. Избыточный вес или ожирение увеличивают материнскую и неонатальную заболеваемость, а женщины с ожирением имеют более высокие показатели бесплодия и повышенный риск различных неблагоприятных исходов беременности. В данном исследовании на основе базы медицинских данных изучается влияние предгестационного ожирения на состояние матери и новорожденного. Цель исследования - оценка влияния ожирения на материнские и неонатальные исходы в третьем триместре беременности и послеродовом периоде. Материалы и методы: В клиническое исследование были включены 88 женщин с одноплодной беременностью и родами, состоявшимися в период с 2021 по 2022 гг. Ретроспективно анализировались осложнения беременности и неонатальные исходы с использованием базы данных регистра рождений в медицинской организации города у беременных с нормальным индексом массы тела (ИМТ 18,5-24,9 кг/м2, n = 41) и предгестационным ожирением (ИМТ ≥30 кг/м2, n = 47). Исходы беременности также сравнивали с учётом степени ожирения (ИМТ в диапазоне 30-34,9 кг/м2, n = 25 и ИМТ ≥35 кг/м2, n = 22). Результаты: У женщин с предгестационным ожирением значительно чаще отмечалась гестационная гипертензия (р <0,0001), преэклампсия (р <0,0001), гестационный диабет (р <0,0001), дистоция плечиков плода (р <0,0001), индуцированные роды (р < 0,0001), неэффективность от индукции родов (р<0,0001), кесарево сечение (р = 0,001), крупный плод (р <0,0001). При этом обращает внимание, что у женщин с ИМТ ≥35 кг/м2 достоверно повышен риск развития гестационного сахарного диабета, преэклампсии, дистоции и рождения новорожденных с оценкой по шкале Апгар ≤7. Заключение: Определено, что женщины с ожирением до беременности имеют более высокий риск развития ряда осложнений (гестационная гипертензия, преэклампсия, гестационный диабет, дистоция, неспособность вызвать роды, родоразрешение крупным плодом и кесарево сечение) в третьем триместре беременности и послеродового периода по сравнению с беременными без ожирения.

Background: Long COVID is a heterogeneous post-viral condition in which persistent neurological, autonomic, cognitive, and psychometric symptoms often occur without clear isolated biomarker abnormalities. This mismatch suggests that disease persistence may be driven not only by changes in individual markers, but by longitudinal reorganization of biological and clinical interactions. Materials and Methods: This observational longitudinal study evaluated patients with persistent symptoms after confirmed SARS-CoV-2 infection at 3 and 6 months. Clinical assessment included neurological examination, Hospital Anxiety and Depression Scale, Beck Depression Inventory, and COMPASS-31. Biomarkers representing hypoxia signaling, oxidative/redox stress, endothelial and renin–angiotensin system activity, glycation-related processes, and complement regulation were analyzed. Correlation analysis, association-level biomarker–clinical network modeling, and complementary Graphical LASSO-based sparse network estimation were used to compare network density, community organization, centrality, and edge rewiring between time points. Results: Conventional paired analysis identified HIF-1$\alpha$ as the only continuous variable with a statistically significant longitudinal change (Wilcoxon statistic = 610.0, $p=0.000350$), whereas association-level network analysis revealed a broader systems-level signal. The association-level biomarker–clinical network preserved a similar global size at 3 and 6 months, with 16 nodes, 27 versus 26 edges, and densities of 0.225 versus 0.217. However, this apparent stability concealed substantial rewiring: 19 edges were shared, 8 were lost, and 7 emerged. Complementary Graphical LASSO analysis with 1000 bootstrap resamples supported this pattern by identifying a conservative sparse conditional-dependency core, including seven shared conditional-dependency edges across time points and selective weakening of four early conditional dependencies. The C3–C4 relationship reversed from negative to positive correlation ($r=-0.618$ to $r=0.618$), indicating marked remodeling of complement-associated regulation. A psychometric–autonomic module involving Beck, HADS I, HADS II, and COMPASS-31 remained stable across both assessments. Conclusions: Long COVID progression was characterized by dynamic remodeling of immune, endothelial/RAS, oxidative-redox, hypoxia-related, autonomic, and psychometric interactions. Longitudinal network analysis identified a systems-level interaction structure that was not captured by isolated biomarker comparisons alone and that was further supported by complementary sparse conditional-dependency analysis.

Formal thought disorder (FTD) is classically associated with schizophrenia-spectrum disorders, but speech disorganization may also occur in other acute psychotic conditions. This study compared eight prespecified FTD phenomena between operationally defined primary and secondary psychotic disorders. In this single-center cross-sectional study, 93 adults admitted with an acute psychotic state to three psychiatric inpatient departments were classified as having primary psychotic disorders (F20/F23.2; n = 51) or secondary psychotic disorders (F06.2/F10.5/F15.5; n = 42). Eight phenomena derived from Andreasen’s descriptions were rated using study-specific 0–2 ordinal anchors. Item-level distributions were analyzed using exact tests with Benjamini–Hochberg correction and covariate-adjusted ordinal regression; composite and diagnostic-subgroup analyses were exploratory. Higher ratings in the primary group were observed for derailment, tangentiality, incoherence, neologisms, and clanging, whereas loss of goal, circumstantiality, and perseveration did not differ statistically. Adjusted models supported the same item-level pattern, and sensitivity analyses supported several principal findings. The exploratory composite was also higher in the primary group (median 10 [8–10.5] vs. 7 [6–8]; p < 0.001). These findings support cautious, descriptive phenomenon-level assessment across acute psychotic disorders but do not validate the framework as a diagnostic instrument or establish disorder-specific FTD profiles.

The purpose of this research was to assess the effectiveness of PRP injections into facial skin and to identify which of the studied blood parameters can affect the effectiveness of the procedure. The research involved 50 women aged 20 to 52 years who received intradermal PRP injections into facial skin. A general examination, complete blood count, and d-dimer, estradiol, and insulin in the blood serum were measured before the procedure, and assessment of the skin’s condition using a facial skin analyzer, assessment of midface volume changes using the Midface Volume Deficit Scale, assessment of aesthetic improvement by the doctor and the patient (Global Aesthetic Improvement Scale, GAIS) before and 1 month after the procedure were conducted for all the subjects involved in the research. According to the GAIS, both from the doctor’s and the patients’ perspectives, the majority noted some improvement in the skin condition after the procedure; however, according to the skin analyzer data, there were no statistically significant changes. A total of 56% of the patients displayed improvement in the midface volume, and this was observed in patients with a lower blood platelet count (≤259 × 10⁹/L) and a higher level of estradiol (>99 pg/mL) before the procedure. No undesirable effects were detected after the procedure.

Введение: В настоящее время, Казахстан по официальной статистике, при сравнении с другими государствами мира имеет более высокий уровень суицида. В связи с этим, возникает необходимость выявления маркеров суицидального поведения для выработки эффективных программ по профилактике самоубийств. Определенные биологические характеристики также могли бы помочь специалистам проводить дифференциальную диагностику истинной суицидальной настроенности с демонстративно-шантажным поведением. Цель: Тезиограмма дает возможность визуально рассмотреть и изучить изменения состава крови. Ранее тезиографическое исследование крови не проводилась на пациентах данного контингента. Материалы и методы: Объектами исследования являются: контрольная группа, состоящая из здоровых людей в количестве 10 человек, а также экспериментальная группа, которая составляла 30 человек, после совершения ими суицидальных попыток. Использовался метод клиновидной дегидратации В.Н. Шабалина и С.Н. Шатохиной. Клинические методы, применявшиеся в данном исследовании, включают в себя психиатрическое интервью с оценкой психического статуса пациента и суицидального риска. Результаты: Изучая тезиографические картины плазмы крови, выделили 3 группы, соответствующие трем морфотипам и имеющих характерологические клинические признаки. Таким образом, отмечается тенденция к отсутствию липидного кольца у большинства образцов, сочетающееся с образованием липидно – белковых структур, что свидетельствует об изменениях обмена в этих группах. Мы предполагаем некоторое соотношение между морфотипом тезиограммы и клинической характеристикой пациентов после совершения суицидальных попыток. Так, например, пациенты, тезиографическая картина которых соответствовала третьему морфотипу имеют более высокий суицидальный риск, когда как пациенты первого морфотипа более низкий. Currently, according to official statistics, Kazakhstan has a higher suicide rate when compared with other countries of the world. Currently, there is a need to identify markers of suicidal behavior in order to develop effective suicide prevention programs. Certain biological characteristics could also help specialists to carry out differential diagnostics of true suicidal mood with demonstrative behavior. A tesiogram makes it possible to visually examine and study changes in blood composition. Previously, a tesiographic blood test was not performed on patients of this contingent. The objects of the study are a control group consisting of healthy people in the number of 10 people, as well as an experimental group, which consisted of 30 people, after they committed suicide attempts. The method of wedge-shaped dehydration was used by V.N. Shabalin and S.N. Shatokhina. The clinical methods used in this study include a psychiatric interview with an assessment of the patient's mental status and suicidal risk. Studying the thesiographic patterns of blood plasma, we identified 3 groups corresponding to three morphotypes and having characterological clinical signs. There is a tendency to the absence of a lipid ring in most samples, combined with the formation of lipid –protein structures, which indicates changes in metabolism in these groups. We assume some correlation between the morphotype of the tesiogram and the clinical characteristics of patients after committing suicide attempts. For example, patients whose thesiographic picture corresponded to the third morphotype have a higher suicide risk, when patients of the first morphotype have a lower one. Қазіргі уақытта, Қазақстан ресми статистика бойынша, әлемнің басқа мемлекеттерімен салыстырғанда суицидтің жоғары деңгейіне ие. Қазіргі уақытта суицидтің алдын алудың тиімді бағдарламаларын әзірлеу үшін суицидтік мінез-құлық белгілерін анықтау қажеттілігі туындайды. Белгілі бір биологиялық сипаттамалар мамандарға демонстрациялық-шантаждық мінез-құлықпен шынайы суицидтік көңіл-күйді дифференциалды диагностикалауға көмектесуі мүмкін. Тезиограмма қан құрамындағы өзгерістерді...

Histomorphometric measurements of the wall thickness and internal diameter of the macrovessels of the chorionic villi of placentas from pregnancies complicated by preeclampsia or fetal growth restriction in comparison with normotensive pregnancy. Methods: The research included placentas from singleton pregnancies complicated by preeclampsia and/or fetal growth restriction, women delivered in medical institutions in Karaganda city (Kazakhstan). Placentas were divided into three groups: PE (n = 59), isolated FGR (n = 24), and PE with FGR (n = 41). The control group consisted of normotensive pregnancies, compared by gestation period. Placental examination and selection of placental tissue fragments were carried out in accordance with the consensus recommendations of the Amsterdam Placental Workshop Group. The sections were stained with hematoxylin and eosin and Masson trichrome. Morphometric measurements were performed using ImageJ software version 1.52p. Results: Our data showed that, in the PE group, there was a significant decrease in the wall thickness of the proximal and distal vessels with an increase in internal diameter compared with the control group (p < 0.01). In the PE + FGR group, there was a thickening of the wall of the proximal part of the vessels with a decrease in their lumen and a decrease in the wall thickness of the vessels with an increase in the lumen in the distal part compared with the control group (p < 0.01). Conclusions: Two histopatterns of placental macrovessels in preeclampsia were revealed: the histophenotype of diffuse (proximal and distal) ectatic macroangiopathy with a thin vascular wall with a decrease in the thickness of the muscle layer and the histophenotype of proximal fibromuscular sclerosis with vascular obliteration/spasm and distal ectatic macroangiopathy. We believe that significant structural differences in vascular remodeling may reflect the different temporal and spatial nature of the pathological factor. Future research is needed to investigate the associations between histopatterns of placental vascular remodeling in preeclampsia and long-term perinatal/maternal outcomes.