We report on a detailed, temperature-dependent, off-resonant Raman scattering study of glassy and supercooled selenium. Raman spectra in the frequency regime of the first-order scattering (5–450 cm−1) have been recorded over a wide temperature range, i.e., 143–353 K. To facilitate the analysis, the spectra have intuitively been divided in three spectral regions. The analysis of the high frequency region (bond-stretching vibrational modes) yielded information on the rings-chains equilibrium. In particular, the polymer content was found to amount to more than 85% around the glass transition temperature, exhibiting a weak temperature dependence, which extrapolates nicely to the high-temperature dissolution data. The intermediate frequency range (representative of the medium-range structural order) was treated together with the low frequency regime (where low-energy excitations, i.e., the quasielastic line and the Boson peak are the dominant contributions) owing to their strong overlap. The study of the bond-bending regime revealed information which made it possible to clarify the role of ringlike and chainlike fragments incorporated in polymeric molecules. The temperature evolution of the Boson peak and the frequency dependence of the Raman coupling coefficient C(ω) were also determined. An attempt to decompose the partial contribution of the pure Boson peak to C(ω) revealed valuable information concerning the limiting (ω→0) behavior of the coupling coefficient.

Amphiphilic self-assembling peptides are functional materials, which, depending on the amino acid sequence, the peptide length, and the physicochemical conditions, form a variety of nanostructures including nanovesicles, nanotubes, and nanovalves. We designed lipid-like peptides with an aspartic acid or lysine hydrophilic head and a hydrophobic tail composed of six alanines (i.e., ac-A₆K-CONH₂, KA₆-CONH₂, ac-A₆D-COOH, and DA₆-COOH). The resulting novel peptides have a length similar to biological lipids and form nanovesicles at physiological conditions. AFM microscopy and light scattering analyses of the positively charged lipid-like ac-A₆K-CONH₂, KA₆-CONH₂ peptide formulations showed individual nanovesicles. The negatively charged ac-A₆D-COOH and DA₆-COOH peptides self-assembled into nanovesicles that formed clusters that upon drying were organized into necklace-like formations of nanovesicles. Encapsulation of probe molecules and release studies through the peptide bilayer suggest that peptide nanovesicles may be good candidates for sustained release of pharmaceutically active hydrophilic and hydrophobic compounds. Lipid-like peptide nanovesicles represent a paradigm shifting system that may complement liposomes for the delivery of diagnostic and therapeutic agents.